Verified laboratory reagents, pure compounds, and peptide sequences supplied with comprehensive HPLC/GC-MS batch analysis.
A rigorous examination of methyl 2-methyl-3-phenyloxirane-2-carboxylate (BMK methyl glycidate) engineering, reaction mechanics, and quality release standards.
CAS 80532-66-7, systematically designated as methyl 2-methyl-3-phenyloxirane-2-carboxylate (also known across downstream manufacturing networks as BMK Methyl Glycidate), represents a specialized substituted oxirane carboxylic ester. Its structural formula encompasses an oxirane (epoxide) three-membered ring substituted by both a methyl group and an ester moiety at C-2, and a phenyl group at C-3. This specific geometry confers unique ring-strain energetics, rendering it an indispensable synthon in stereoselective organic transformations.
The oxirane ring system exhibits substantial angular strain (approximately 114 kJ/mol), making CAS 80532-66-7 highly reactive toward nucleophiles under catalyzed conditions. Factory-scale handling requires meticulous thermodynamic monitoring: ambient thermal profiles must be stabilized between 2°C and 8°C to prevent spontaneous autoxidation, moisture-induced ester hydrolysis, or uncontrolled dimerization across extended storage windows.
| Technical Metric | Empirical Parameter Specification |
|---|---|
| Chemical CAS Identifier | 80532-66-7 |
| Empirical Formula | C11H12O3 |
| Molecular Weight | 192.21 g/mol |
| Physical Appearance | Pale yellow transparent liquid to crystalline off-white mass (temp dependent) |
| Assay Standard (GC/HPLC) | ≥ 99.2% (Sum of stereoisomeric enantiomers) |
| Boiling Point (760 mmHg) | 295.4 ± 35.0 °C (Calculated baseline) |
| Density (20°C) | 1.14 ± 0.05 g/cm³ |
| Refractive Index (nD20) | 1.520 – 1.528 |
| Residual Acid (as Glycidic Acid) | ≤ 0.15% w/w (Potentiometric titration) |
| Storage Recommendations | Sealed nitrogen-purged drums, 2–8°C, dark, dry environment |
Market segmentation, international regulatory governance, and the supply-demand matrix driving modern fine chemical synthesis.
Over the last five years, the global sourcing vector for specialized phenylglycidate derivatives has consolidated heavily around certified industrial manufacturing hubs capable of guaranteeing multi-ton output. Industrial buyers in pharmaceutical intermediate manufacturing and flavor/fragrance ester synthesis require dependable contracts with verified delivery timeframes, mitigating spot-market price volatility and speculative quality discrepancies.
Because downstream transformations of BMK glycidates are subject to heightened regulatory categorization under multilateral chemical control conventions (including EU precursor monitoring frameworks and US DEA Class II scheduling mechanisms), legitimate industrial procurement necessitates comprehensive end-user declaration (EUD) verification, audited export documentation, and complete dual-use customs reporting.
Factory-direct economics are fundamentally driven by upstream petrochemical commodity feeds—principally benzaldehyde and chloroacetate esters. Modern automated facilities that maintain captive raw material supplies demonstrate superior price resistance, offering enterprise purchasers long-term off-take pricing stability compared to regional trading intermediaries.
How Hebei manufacturing clusters combine automated micro-channel reactors, vertical feed integration, and stringent green chemistry controls.
Our manufacturing complex located in the industrial chemical belts of Hebei benefits from immediate proximity to basic bulk petrochemical inputs: chlorine, sodium methoxide, toluene, and methyl chloroacetate. By integrating basic upstream precursors on-site, Chinese manufacturing plants bypass secondary freight markups, tariff friction, and intermediary supply bottlenecks. This structural economy of scale translates to a 30% to 45% production cost advantage over decentralized European or North American pilot synthesis setups, without compromising analytical reproducibility or environmental safeguards.
Traditional batch-pot Darzens condensations frequently suffer from localized hot-spots, uneven base distribution, and hazardous exotherms that degrade glycidic ester yields and elevate isomer impurity rates. Leading Hebei facilities utilize continuous flow tubular micro-channel reactors. Micro-reactors provide extraordinary surface-area-to-volume ratios, allowing millisecond heat transfer, strict stoichiometric addition of sodium methoxide, and constant reaction temperature maintenance at ±0.5°C. This technological leap eliminates thermal degradation, suppresses polymeric tar formation, and guarantees lot-to-lot homogeneity.
Comprehensive overview of catalytic transformations, fragrance formulation, pharmaceutical reference materials, and academic research models.
In authorized organic synthesis laboratories, CAS 80532-66-7 serves as an essential benchmark substrate for investigating thermodynamic decarboxylation kinetics. Cleavage of the ester moiety via alkaline saponification produces sodium 2-methyl-3-phenyloxirane-2-carboxylate, which undergoes subsequent proton-catalyzed ring-opening and spontaneous decarboxylation to yield 1-phenyl-2-propanone derivatives. This model reaction is widely studied in university and industrial labs to quantify transition-state carbocation stability.
Glycidic acid esters represent a vital building block class within the specialized synthetic perfumery sector. Substituted oxirane carboxylates impart strawberry-, berry-, and honey-like sensory top-notes. CAS 80532-66-7 is deployed in fine chemical aroma synthesis to produce tailored floral-fruity base notes, where stability in alkaline personal-care formulations and high fixation tenacity are paramount commercial requirements.
State toxicological laboratories, national customs inspection departments, and third-party contract research organizations (CROs) require ultra-high-purity (≥99.5%) neat standards of CAS 80532-66-7. These materials calibrate gas chromatography-mass spectrometry (GC-MS), high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS), and nuclear magnetic resonance (NMR) libraries for global inter-laboratory validation.
How Hebei Miaoou Technology enforces uncompromising pharmaceutical-grade testing standards for every synthesized batch.
Every industrial production run of CAS 80532-66-7 is subject to a rigorous release battery before dispatch. Our in-house analytical testing center applies four complementary analytical modalities:
In accordance with ISO 9001 and Good Manufacturing Practice guidelines, every shipping drum is assigned a unique alphanumeric lot identifier tied to:
Transitioning from toxic legacy reagents to green catalytic oxidation and AI-driven continuous micro-reactor loops.
Traditional Darzens condensation routes inherently generate stoichiometric quantities of sodium chloride and organic alcohol by-products. The chemical industry is vigorously exploring next-generation epoxidation methodologies, including direct catalytic olefin oxidation using aqueous hydrogen peroxide (H₂O₂) over titanium-silicate catalysts (TS-1). This green route drastically cuts hazardous waste disposal fees, enhances the environmental safety score, and reduces the global carbon footprint of bulk manufacturing.
Factory automation systems at Hebei Miaoou integrate artificial intelligence neural networks with in-line Raman and NIR sensors. Real-time feedback loops adjust pump pressure, reaction temperatures, and feed ratios in millisecond intervals. If minor temperature fluctuations occur within the micro-reactor zone, the AI controller modulates residence time automatically, maintaining target stereoisomer purity consistently above 99.2% without human intervention.
Modern ecological standards demand absolute solvent recovery. Our production lines feature multi-stage continuous vacuum distillation columns that reclaim over 96.5% of process alcohols and non-polar reaction solvents. Reclaimed solvents undergo molecular-sieve dehydration and are reintroduced into the primary synthesis cycle, suppressing environmental effluent discharge and lowering raw material consumption indexes.
Comprehensive compliance roadmap for international procurement managers, supply chain auditors, and logistics directors.
To eliminate moisture ingress and preserve the integrity of the oxirane ring, CAS 80532-66-7 is packed under dry nitrogen blanket in UN-rated high-density polyethylene (HDPE) drums or epoxy-lined steel drums. Available options range from 25 kg fluorinated plastic canisters to 200 kg heavy-gauge drums, and 1,000 kg intermediate bulk containers (IBCs). Secondary vacuum foil bags protect palletized consignments from maritime humidity and saline air corrosion.
Navigating global border clearance requires flawless technical and regulatory paperwork. Every shipment executed by our export division is accompanied by:
We accommodate enterprise incoterms including FOB Tianjin/Shanghai, CIF destination seaports, and air freight via temperature-controlled air couriers. For designated international commercial partners, our seasoned customs operations team coordinates direct freight forwarding networks capable of managing customs entry documentation, ensuring seamless port-of-entry transit without administrative demurrage delays.
In-depth responses to the most critical technical, commercial, and operational questions posed by industrial buyers.
All commercial factory production batches manufactured by Hebei Miaoou Technology Co., Ltd. are certified at a minimum purity of 99.0% by GC-FID and HPLC assay. Typical production batches consistently achieve 99.3% to 99.6% purity, with individual organic impurities restricted below 0.20% and moisture content verified at or below 0.10% by Karl Fischer titration. An individualized Certificate of Analysis accompanies every dispatched drum.
Continuous flow micro-reactors provide sub-millimeter reaction zones with instantaneous heat dissipation. In contrast to legacy 5,000-liter batch reactors—which suffer from localized temperature spikes and prolonged base contact that trigger epoxide ring dimerization—continuous flow equipment ensures uniform stoichiometry and residence time down to fractions of a second. This results in virtually zero polymeric resin formation, higher crystalline purity upon cooling, and a substantially longer shelf life.
CAS 80532-66-7 must be stored in airtight, nitrogen-purged containers shielded from direct sunlight and environmental humidity. Recommended warehouse storage temperatures are between 2°C and 8°C for optimal long-term chemical preservation, although ambient warehouse storage (below 25°C) is acceptable for short intervals under inert gas blankets. Containers should never be exposed to acidic or alkaline vapors, which catalyze rapid oxirane ring breakdown.
Yes. In addition to our internal quality release dossiers, we welcome pre-shipment third-party sampling and testing by globally recognized inspection agencies such as SGS, Bureau Veritas, or customer-designated GLP-certified analytical laboratories. Blinded split samples can be verified by independent NMR, HPLC, and GC-MS protocols prior to balance settlement.
Our Shijiazhuang manufacturing facilities operate at a baseline output capacity of 40 to 60 metric tons per month of specialized phenylglycidate esters. For standard stock orders (up to 500 kg), goods can be packaged and dispatched to domestic export ports within 48 to 72 hours. Customized industrial contracts ranging from 1 to 10 metric tons require an average production lead time of 7 to 14 business days, inclusive of analytical quarantine and final release validation.
We support multiple international payment structures tailored to enterprise procurement security, including Telegraphic Transfer (T/T), formal proforma invoice arrangements, and Escrow-based settlement structures for qualified institutional buyers. All commercial transactions are accompanied by legal corporate invoicing, transparent tax compliance receipts, and verified bill of lading documentation.
Premium reference peptides, specialized hormone analogues, and research powders with direct factory pricing and immediate availability.
