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CAS 14769-73-4 identifies the levorotatory stereoisomer (S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole, an essential bioactive compound utilized internationally as an anthelmintic agent and immune-response modifier.
| Analytical Parameter | Acceptance Criteria (EP / BP / USP) | Typical Miaoou Technology Batch Result | Testing Methodology |
|---|---|---|---|
| Chemical Name | (-)-(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole | Conforms to Structure | 1H-NMR, 13C-NMR & FT-IR |
| CAS Registry Number | 14769-73-4 (Free Base) / 16595-80-5 (Monohydrochloride) | Matched Registry Verification | CAS Authority Cross-Verification |
| Molecular Formula / Weight | C11H12N2S / 204.29 g/mol (Base), 240.75 g/mol (HCl) | 204.29 / 240.75 | High-Resolution MS (ESI-TOF) |
| Physical Appearance | White to almost white crystalline powder | Pure crystalline white micro-powder | Visual Inspection / Colorimetry |
| Assay (Purity on Dry Basis) | 98.5% – 101.5% | 99.82% | Potentiometric Titration / HPLC |
| Enantiomeric Purity (Chiral) | (S)-Isomer ≥ 99.0%; (R)-Isomer ≤ 0.5% | (S)-Isomer: 99.78% (ee > 99.5%) | Chiral HPLC (Chiralpak IC Column) |
| Specific Optical Rotation [α]D20 | -121.5° to -128.0° (c=5, H2O on dry basis) | -125.8° | Automatic Polarimeter @ 589nm |
| Melting Point Range | 226.0°C to 231.0°C (HCl salt degradation) | 228.4°C – 229.6°C | Capillary Melting Point (DSC) |
| Heavy Metals (Pb, Cd, As, Hg) | ≤ 10 ppm total; Individual heavy metals < 2 ppm | < 5 ppm total | ICP-MS (Inductively Coupled Plasma) |
| Related Impurities (Total) | Total related substances ≤ 0.5%; Any individual ≤ 0.2% | Total: 0.18%; Max single: 0.07% | Reverse-Phase HPLC (UV @ 215nm) |
| Loss on Drying | ≤ 0.50% (105°C, 4 hours) | 0.14% | Thermogravimetric Analysis |
Strategic analysis of procurement trends across major veterinary manufacturing hubs, pharmaceutical fine chemical synthesizers, and contract research organizations (CROs).
Procurement teams across the United States and Canada face heightened regulatory scrutiny regarding supply authenticity, trace contamination screening, and strict DEA/FDA non-adulteration verifications. Enterprise buyers demand fully vetted supply partners who provide robust cGMP documentation, audited production traceability, and certified lot-to-lot consistency.
European Union importers mandate uncompromising adherence to the European Pharmacopoeia (EP) monograph for Levamisole Hydrochloride. The strict limitations on 3-(2-mercaptoethyl)-5-phenylimidazolidin-2-one and other degradation byproducts require high-efficiency purification steps. Miaoou Technology’s supply route guarantees zero unmonitored impurities.
Livestock-heavy markets in Brazil, Argentina, Australia, and New Zealand experience recurring seasonal spikes for high-volume veterinary anti-parasitic drenches and feed additives. Miaoou maintains dedicated stock reserves, allowing agricultural formulators to lock in multi-ton forward contracts without risking spot-market price inflation or shipment delays.
A key vulnerability in commercial sourcing is the deceptive substitution of racemic tetramisole (a 50:50 mixture of d- and l-enantiomers) in place of high-value optical pure Levamisole (CAS 14769-73-4). Our optical rotation certs and chiral chromatography assays protect enterprise clients from sub-potent or non-compliant formulations.
Addressing supply vulnerabilities with dual-sourcing precursor chemistry, optimized freight routes, and full customs documentation mitigation.
The industrial synthesis of Levamisole base relies on precise precursors including 2-amino-2-thiazoline, styrene oxide derivatives, and resolving chiral acids (such as D-camphorsulfonic acid). Supply disruptions in standard chemical intermediates often cripple smaller chemical traders.
Hebei Miaoou Technology mitigates upstream volatility through long-term backward integration. By directly synthesizing our organic intermediates and operating dual-plant continuous crystallization loops in Hebei, our factory eliminates the single-source failure point, providing commercial buyers with a predictable, scalable monthly output capacity exceeding 25 metric tons.
We furnish comprehensive customs documentation—including unified HS codes (2934.99.9000), verified technical data sheets, and destination-specific commercial invoices. Our freight partners specialize in rapid port clearance across Rotterdam, Los Angeles, Melbourne, and Santos.
Levamisole base and its hydrochloride salt are vulnerable to atmospheric oxidation and moisture adsorption over transatlantic routes. We package bulk orders in multi-layered pharmaceutical foil liners under inert nitrogen atmospheres inside UN-rated fiber drums to preserve physical stability.
Every lot manufactured in our factory carries an unbroken electronic batch record (EBR). We offer vendor qualification audit packs including process flow diagrams (PFDs), residual solvent declarations (ICH Q3C), elemental impurity studies (ICH Q3D), and verified COAs.
A rigorous examination of our stereoselective synthesis pathways, chiral resolution mechanisms, and modern green chemistry initiatives.
Reaction of 2-aminothiazoline with phenacyl bromide or styrene oxide to form the bicyclic core intermediate under temperature-regulated vessel conditions.
Cyclization yields racemic (±)-tetramisole. The crude reaction mixture undergoes multi-stage solvent extraction to isolate clean, unseparated enantiomeric salts.
Application of D-(+)-camphorsulfonic acid (D-CSA) facilitates preferential diastereomeric salt crystallization, achieving isolation of pure (S)-isomer crystals.
The undesired (R)-dextramisole filtrate undergoes thermal/alkaline racemization, looping directly back into Stage 03 to eliminate hazardous chemical yield loss.
Controlled acidification using anhydrous hydrogen chloride gas in ethanol/acetone media generates the final, ultra-pure crystalline powder (CAS 14769-73-4).
Our quality control laboratories utilize Agilent 1260/1290 Infinity II HPLC systems coupled with diode-array detection (DAD) and triple-quadrupole mass spectrometers (LC-MS/MS). The target analyte Levamisole (CAS 14769-73-4) is resolved on reversed-phase C18 stationary phases (4.6 mm × 250 mm, 5 µm) utilizing an optimized phosphate buffer/acetonitrile mobile phase gradient.
Specialized chiral resolution checks are run in parallel using Chiralpak IC columns to detect even fractional traces of Dextramisole (CAS 14769-74-5). This guarantees enantiomeric excess (ee > 99.5%), ensuring pharmaceutical formulators receive zero bio-inactive or toxic enantiomer carryover.
Understanding how Levamisole's dual pharmacological properties drive sustained procurement across global veterinary, biomedical, and specialty synthesis sectors.
Levamisole functions as a selective nicotinic acetylcholine receptor (nAChR) agonist in nematode nerve and muscle tissue. Prolonged depolarizing neuromuscular blockade results in rapid worm spastic paralysis, allowing hosts to expel target nematodes (including Haemonchus, Trichostrongylus, and Dictyocaulus). It is globally deployed in sheep, cattle, and swine veterinary drenches.
Beyond anti-parasitic activity, Levamisole uniquely restores depressed cell-mediated immune functions by stimulating T-lymphocyte proliferation, upregulating macrophage and neutrophil phagocytosis, and stimulating cyclic GMP production. Research centers continue to investigate Levamisole as an immune adjuvant in clinical oncology and immune deficiency research models.
In organic chemistry, the rigid bicyclic thiazole core of CAS 14769-73-4 serves as a chiral ligand precursor and structural scaffold for specialized asymmetric synthesis. Contract synthesis facilities source pharmaceutical-grade Levamisole base for bespoke downstream derivatizations requiring pre-existing chiral stereocenters.
Ensuring frictionless market access through comprehensive audit trails, REACH registrations, and proactive compliance architecture.
Hebei Miaoou Technology operates state-of-the-art cleanrooms adhering strictly to ICH Q7 good manufacturing practice guidance for active pharmaceutical ingredients. Production lines undergo rigorous annual third-party compliance audits.
We provide full Only Representative (OR) coverage under EU REACH regulations, enabling European chemical distributors and livestock pharmaceutical formulators to import CAS 14769-73-4 without tonnage band restrictions or hazardous compliance obstacles.
To bypass potential shipping bottlenecks and non-tariff trade barriers, our in-house trade specialists pre-file export permits, non-dual-use declarations, and comprehensive MSDS documentation localized in English, Spanish, German, and French.
We accommodate desktop vendor documentation audits, real-time video facility inspections, and pre-scheduled on-site manufacturing audits at our Shijiazhuang production facilities for strategic multi-year procurement partners.
Operating since 2010, our chemical synthesis campus in Hebei delivers industrial-scale consistency, dedicated customer service, and absolute analytical integrity.
Over 16 years of continuous specialization in fine chemical synthesis, peptide lyophilization, and pharmaceutical bulk distribution.
Consistently outperforming pharmacopeial minimum thresholds through proprietary multi-pass recrystallization systems.
Our dedicated technical sales and logistics departments provide comprehensive proforma quotations, COAs, and answers within 24 hours.
Hebei Miaoou Technology Co., Ltd. welcomes qualified global enterprises, formulation chemists, and bulk purchasing directors to connect with our international export division for contract manufacturing, toll synthesis, or catalog sourcing.
Facility Address: Room 1908, Building 6, Lucheng Business Center, 219 Xinhua Road, Shijiazhuang, Hebei, China.
Direct Inquiries: [email protected] | Telephone: +852 9862 1364
Authoritative answers addressing chemical identity, testing protocols, export paperwork, minimum order quantities, and contract terms.
CAS 14769-73-4 represents the free base molecule ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole) with a molecular weight of 204.29 g/mol, which is oil- or alcohol-soluble and commonly selected for specific non-aqueous liquid concentrates or fine organic syntheses. In contrast, CAS 16595-80-5 is the monohydrochloride salt (molecular weight 240.75 g/mol), which provides high aqueous solubility, elevated melting points, and extended shelf stability. Both grades are manufactured in our Hebei facilities to full EP/USP standards.
Each batch undergoes strict chiral HPLC analysis on Chiralpak IC phases alongside automated optical rotation quantification ([α]D20 = -121.5° to -128.0°). Racemic tetramisole exhibits zero net optical rotation ([α]D = 0°), making any batch contamination immediately visible. Our Certificates of Analysis explicitly state the enantiomeric excess (ee value > 99.5%) alongside full chiral chromatographic data.
Our standard trial MOQ for validated laboratory and evaluation trials is 1 kilogram. Commercial and contract production is typically packaged in 25 kg multi-wall UN-approved fiber drums fitted with double polyethylene interior liners and optional vacuum aluminum-foil barrier sleeves. Customized packaging (from 100g sample containers to 500kg bulk shipping totes) is fully available upon request.
Yes. In addition to our internal QA/QC release reports, we routinely coordinate blind re-testing through certified global testing agencies (including SGS, Eurofins, and Intertek) for clients requesting independent verification of potency, heavy metal ceilings, or absence of residual solvents prior to shipment dispatch.
We manage international air freight and maritime shipping through specialized chemical freight forwarders. Our export department provides full document packages: Bill of Lading / Air Waybill, Commercial Invoice, Packing List, Certificate of Origin, Detailed COA, and GHS-compliant Safety Data Sheets (SDS). We track every consignment continuously until signed delivery confirmation at your designated destination port or facility.
We accept standard corporate international payment rails including Wire Transfer (T/T), Letter of Credit (L/C) for verified high-volume container shipments, and escrow-backed alternatives. Multi-year recurring supply agreements with indexed pricing clauses are available to qualified long-term veterinary and pharmaceutical partners.
Review additional factory direct offerings, available with immediate dispatch, comprehensive documentation, and global courier handling.
Connect directly with our chemical engineering and export dispatch team. Inquire about current batch availability for CAS 14769-73-4, request specialized packaging quotes, or schedule a formal quality audit.
