Procure certified pharmaceutical actives, signaling peptides, and essential solvent precursors tested under certified ISO/cGMP protocols.
Detailed chemical parameters, thermodynamic traits, and analytical standards required by global synthesis operations seeking verified Cas 110-86-1 manufacturer and manufacturers.
Pyridine (CAS Registry Number 110-86-1) is an essential heterocyclic organic intermediate with the empirical formula C₅H₅N and a molecular weight of 79.10 g/mol. Characterized by a planar six-membered aromatic ring containing one tertiary nitrogen atom with a solitary lone electron pair, it exhibits a distinct, mildly pungent tertiary amine scent and is completely miscible with water, ethanol, and diethyl ether.
As an electron-deficient aromatic nucleophile, CAS 110-86-1 acts as a mild Lewis base (pKa of conjugate acid 5.25), functioning as an optimal acid scavenger during acylation, sulfonylation, and esterification reactions in peptide and antibiotic synthesis workflows.
Top-tier manufacturers supply CAS 110-86-1 in multiple grades: Industrial Synthesis Grade (≥99.5%), Anhydrous Biotech Grade (≥99.9%, H₂O < 50 ppm), and Spectroscopic Grade. Controlling trace moisture and reducing side contaminants (such as methylpyridines / picolines) prevents adverse reaction kinetics during sophisticated pharmaceutical cyclizations.
Each exported delivery should be accompanied by calibrated Gas Chromatography (GC-FID), Karl Fischer moisture titration, and full trace elemental analysis by ICP-OES to satisfy strict regulatory import inspections.
| Parameter / Specification | Standard Industrial Grade | High-Purity Pharma / Synthesis Grade | Test Methodology |
|---|---|---|---|
| Appearance | Clear, colorless to light yellow liquid | Clear, transparent, colorless liquid | Visual Inspection |
| Assay Purity (GC) | ≥ 99.50% | ≥ 99.90% | Gas Chromatography (Capillary FID) |
| Water Content (KF) | ≤ 0.10% (1000 ppm) | ≤ 0.005% (50 ppm Max) | ASTM E1064 Coulometric KF |
| Boiling Point Range | 114.5 – 116.0 °C | 115.0 – 115.6 °C | Distillation Range (ASTM D1078) |
| Non-Volatile Residue | ≤ 0.005% | ≤ 0.001% | Gravimetric Analysis (105 °C) |
From API formulation to agricultural agrochemicals, explore the core reasons chemical synthesis enterprises procure CAS 110-86-1 at commercial scales.
CAS 110-86-1 is an indispensable building block for anti-infective, anti-histaminic, and analgesic therapeutics. It acts as an intermediate for compounds including sulfapyridine, piroxicam, tripelennamine, and targeted oncology small molecules. In solid-phase peptide synthesis (SPPS), anhydrous pyridine controls activation kinetics without racemizing fragile stereocenters.
Large-scale global buyers source bulk quantities of Pyridine to synthesize major agricultural chemicals, notably paraquat, diquat, chlorpyrifos, and substituted pyridine-based herbicides. The consistent availability of CAS 110-86-1 direct from primary manufacturers stabilizes global food supply chain chemistries.
Karl Fischer moisture determination reagents utilize high-purity pyridine buffers to stabilize sulfur dioxide and maintain precise pH levels. Furthermore, in polymer industries, it serves as a cross-linking accelerator and catalyst in polycarbonate manufacture and synthetic rubber vulcanization.
How state-of-the-art Chinese chemical synthesis clusters integrate feedstocks, automation, and green manufacturing to deliver unprecedented cost-to-quality ratios.
Chinese chemical parks integrate acetaldehyde, formaldehyde, and ammonia feedstocks via fluid bed catalytic processes (such as the Chichibabin pyridine synthesis), protecting production volumes against raw precursor price spikes.
Continuous multistage vacuum rectification columns cleanly remove difficult isomeric impurities such as 2-picoline and 3-picoline, guaranteeing ultra-low residue levels (≤ 10 ppm) suitable for sensitive GMP biological manufacturing.
Orders are packaged under strict nitrogen blankets into UN-approved 200L steel drums (190kg/200kg net), 1000L IBC composite totes, or dedicated ISO-tanks (20-24 MT) fitted with vapor recovery valves to halt moisture re-absorption.
Continuous closed-loop scrubbing systems minimize emissions and satisfy modern ESG mandates, shielding long-term purchasing programs from regulatory shutdown risks during local environmental evaluations.
Navigating customs protocols, classification codes, and hazardous substance management across major economic territories.
Under EU Regulation (EC) No 1907/2006 (REACH), Pyridine imports exceeding 1 MT/year mandate valid registration dossiers. Our factory works alongside appointed Only Representatives (OR) to provide full tonnage coverage, certified 16-section SDS in multiple languages, and CLP-compliant GHS hazard labelling (Flammable Liquid Cat 2, Acute Tox Cat 4).
Consignments entering North American ports require active TSCA inventory verification, proper DOT hazardous material classification (UN 1282, Class 3, Packing Group II), and Hazmat-trained freight handling. We supply complete Certificates of Origin, commercial customs declarations, and US EPA documentation to facilitate expedited clearance through US CBP.
From Korea REACH (K-REACH) and Japan CSCL to Middle East SASO/SABER approvals, localized documentation teams tailor phytosanitary, fumigation, and pre-shipment SGS/BV analysis certificates to match country-specific port authority regulations without unexpected demurrage.
Technological innovations shaping the market landscape of CAS 110-86-1 for forward-looking chemical procurement managers.
Conventional batch reactors are transitioning toward continuous flow micro-channel synthesis. This methodology drastically curtails byproduct formation, provides ultra-precise temperature control, and enables tighter tolerance controls over hazardous reaction intermediates.
Industrial clients prioritize factories utilizing solid-acid and zeolite-based regeneration setups. Modern facilities reclaim up to 92% of spent pyridine from effluent washes, satisfying carbon-reduction objectives and circular chemistry initiatives.
Quality release protocols incorporate automated online GC-MS and head-space analysis to detect trace nitrosamines and volatile organic compounds (VOCs), ensuring compliance with ICH Q3A/B pharmaceutical guidelines.
Essential guidance covering technical specifications, MOQ requirements, global dangerous goods logistics, and analytical documentation.
Standard industrial synthesis grade typically offers a minimum assay of 99.5% by GC. However, for specialized API cyclization, peptide synthesis, and spectroscopic usage, manufacturers synthesize high-purity anhydrous grade at ≥ 99.90% with water content suppressed below 50 ppm (0.005%) measured by coulometric Karl Fischer analysis.
Every commercial delivery includes a batch-specific Certificate of Analysis (COA), an official GHS-compliant 16-section Safety Data Sheet (SDS/MSDS), Gas Chromatography (GC) trace chromatograms, a Dangerous Goods Declaration (DGD), a Packing List, and a Certificate of Origin (CO). Third-party SGS or Intertek inspection reports can be provided upon request prior to loading.
Pyridine is internationally recognized as Class 3 Flammable Liquid (Sub-risk: Toxic/Irritant depending on local regulations), assigned to UN Number 1282, Packing Group II. It must be transported in UN-approved steel drums or ISO-tanks by licensed DG freight haulers who strictly follow IMDG, ICAO/IATA, and ADR international carrier rules.
Yes. Depending on your downstream operational infrastructure, CAS 110-86-1 can be filled under positive-pressure dry nitrogen atmosphere into 200L drums, 1000L IBC intermediate bulk containers, or 20-foot ISO tanks. Pallets are secured with anti-static wrap, and custom corporate labeling can be matched to your local internal warehouse ERP identification system.
For trial evaluation and laboratory verification, sample containers ranging from 1L to 25L can be expedited via specialized hazardous chemical couriers. For sea-freight commercial manufacturing orders, standard MOQ starts at 1 pallet (4 × 200kg drums = 800kg). Factory dispatch typically executes within 5 to 7 business days from order confirmation and compliance approval.
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