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| Item | Specification |
|---|---|
| Product Name | Retatrutide |
| CAS NO. | 2381089-83-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731.33 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in water or 0.9% saline solution; compatible with standard buffers |
| Endotoxin | ≤ 0.1 EU/mg |
| Biological Activity | Potent agonist for GLP-1, GIP, and glucagon receptors; promotes weight loss & glucose control |
| Storage Conditions | Store at 2–8°C protected from light; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
The mechanism of action of Retatrutide is characterized by its unique triple-agonist profile, which integrates the effects of three key metabolic hormones. By activating GLP-1 receptors, it enhances insulin secretion and suppresses glucagon release in a glucose-dependent manner while slowing gastric emptying to increase satiety; through GIP receptor agonism, it improves insulin sensitivity and may potentiate the effects on adipose tissue; and critically, by activating the glucagon receptor, it increases energy expenditure and promotes lipolysis, thereby creating a synergistic effect that not only reduces appetite but also actively burns stored fat.
Retatrutide is indicated for the treatment of adults with obesity (BMI ≥30 kg/m²) or overweight (BMI ≥27 kg/m²) with at least one weight-related comorbidity, as well as for the management of type 2 diabetes mellitus. It is particularly suitable for patients seeking substantial weight loss beyond what is typically achievable with lifestyle modifications or first-line pharmacotherapies, including those who may be considering bariatric surgery but prefer a non-surgical alternative, and individuals requiring robust glycemic control alongside significant body weight reduction.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Each batch includes COA, HPLC purity report, MS chromatograms, and third-party testing reports.
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation. We can also customize packaging according to customer needs.
Main Method: International Air Freight (DHL, FedEx, UPS, TNT). Air freight ensures the fastest transit time and minimizes environmental impact.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications.
Retatrutide is an experimental medication being studied for obesity and metabolic disease. It activates three key hormone receptors: GLP-1, GIP, and glucagon. By stimulating GLP-1 and GIP pathways, it significantly reduces hunger and food intake. At the same time, its glucagon receptor activity may slightly increase energy expenditure. This combination creates a sustained calorie deficit, which leads to fat loss. In summary, it creates biological conditions that lead the body to gradually reduce stored fat.
One of the most notable benefits is substantial weight loss, often exceeding results seen with Tirzepatide. Beyond weight management, it has demonstrated improvements in metabolic health, lowering blood glucose levels and improving insulin sensitivity. It also shows potential in reducing liver fat and improving cardiovascular risk factors like triglycerides and LDL cholesterol.
Retatrutide is still an investigational drug and has not yet received full regulatory approval from agencies like the FDA. The primary way to access it right now is through participation in clinical trials. It is important to be cautious about online sources claiming to sell retatrutide, as unregulated products may be unsafe or counterfeit.
Unlike single or dual agonists, Retatrutide integrates three metabolic pathways: GLP-1 enhances insulin secretion and slows gastric emptying; GIP improves insulin sensitivity; and glucagon receptor activation drives energy expenditure and lipolysis. This dual approach curbs calorie intake while accelerating fat burning.
To maintain product integrity and chemical stability, Retatrutide lyophilized powder should be stored at 2–8°C protected from light. Repeated freeze-thaw cycles must be strictly avoided.
Every batch undergoes rigorous quality control and includes a Certificate of Analysis (COA), high-performance liquid chromatography (HPLC) purity verification (≥98.0%), mass spectrometry (MS) chromatograms, and qualified third-party laboratory testing reports.
