Direct supply from Hebei Miaoou Technology facility with complete analytical verification, export clearance, and temperature-controlled freight.
Comprehensive characterization of 2-Phenylacetamide (CAS 103-81-1) produced under rigid quality surveillance protocols at our Hebei manufacturing complex.
2-Phenylacetamide (also designated as Benzeneacetamide, α-Phenylacetamide, or Phenylacetamide; CAS Registry Number: 103-81-1) represents an essential mono-substituted aromatic amide intermediate. Operating at the core of β-lactam antibiotic synthesis, heterocyclic functionalization, and agrochemical active ingredient formulation, this white crystalline solid demands exact control over crystallographic polymorphism, residual nitrile presence, and trace volatile organics.
| Analytical Parameter | Pharmacopeial / Industrial Standard | Miaoou Ultra-Pure Specification | Methodology |
|---|---|---|---|
| IUPAC Name | 2-Phenylacetamide | 2-Phenylacetamide | Structure Verification |
| CAS Registry Number | 103-81-1 | 103-81-1 | Chemical Abstract Service |
| Chemical Formula / MW | C₈H₉NO / 135.16 g/mol | C₈H₉NO / 135.16 g/mol | High-Res Mass Spec (HRMS) |
| Assay Purity (HPLC) | ≥98.5% w/w | ≥99.20% – 99.85% w/w | Reverse Phase HPLC-DAD (210nm) |
| Physical Appearance | White to off-white crystalline flakes | Snow-white crystalline powder / flakes | Visual / Colorimetric (APHA ≤10) |
| Melting Range | 156.0 °C to 159.0 °C | 156.5 °C to 158.0 °C (sharp onset) | Capillary Melting Point / DSC |
| Loss on Drying (LOD) | ≤0.50% | ≤0.20% max | Gravimetric (105 °C, 2h) |
| Residual Nitrile (Phenylacetonitrile) | ≤0.20% | ≤0.05% (500 ppm max) | Headspace GC-FID |
| Sulfate Ash (Residue on Ignition) | ≤0.10% | ≤0.03% | Muffle Furnace (600 °C) |
| Heavy Metal Limits | ≤20 ppm total | ≤5 ppm (ICH Q3D Compliant) | ICP-MS |
Standard market grades of 2-Phenylacetamide synthesized through aggressive mineral acid hydration of benzyl cyanide typically suffer from dark discoloration, sulfuric ester contaminants, and stubborn residual benzyl cyanide traces. At Hebei Miaoou Technology Co., Ltd., we utilize an engineered, zero-cyanide discharge, catalytic hydration process using reusable heterogeneous manganese dioxide/metal-organic framework (MOF) biocatalytic analogues. This green catalytic route allows nearly 100% atom efficiency with absolute control over exothermic runaway, producing a crystalline intermediate free of chlorinated aromatics and heavy sulfate residues.
Navigating global regulatory shifts, dual-use oversight, active pharmaceutical ingredient (API) reshoring, and the strategic positioning of Chinese chemical manufacturing.
The international fine chemical industry is undergoing unprecedented systemic transformation. Between 2024 and 2030, demand for aromatic amide precursors is projected to expand at a CAGR of 6.2%, propelled by antibiotic fermentation demand in developing markets, new clinical trials in central nervous system (CNS) anticonvulsants, and agricultural peptide-mimetic protectants.
China continues to account for over two-thirds of the world's upstream supply of phenylacetic acid and 2-phenylacetamide, providing essential scale economies and continuous raw material security for world health systems.
Procurement teams demand rapid-turnaround regulatory packages. We supply complete open-part Drug Master File (DMF) sections, BSE/TSE statements, and elemental impurity profiles within hours of request.
Multi-layered anti-static polythene liners enclosed in UN-rated steel-reinforced fiber drums preserve desiccated crystalline morphology during multi-week ocean transit across equatorial routes.
In modern chemical economics, 2-Phenylacetamide serves as an indispensable synthon across three multi-billion-dollar therapeutic sectors:
Meeting rigorous international customs standards across EU REACH, US TSCA, and international dual-use chemical surveillance networks.
Sourcing chemical compounds from international manufacturers introduces compliance risks if documentation is improperly formatted or regulatory lists are disregarded. Hebei Miaoou Technology Co., Ltd. (operating continuously since 2010) has instituted a comprehensive cross-border compliance mechanism designed to guarantee frictionless clearance across European, North American, Latin American, and Asian ports of entry.
Every commercial lot exported to the European Economic Area (EEA) complies with EU REACH (Regulation EC No 1907/2006). For US-bound research and industrial procurement, compounds are certified in strict accordance with the Toxic Substances Control Act (TSCA) inventory guidelines.
While 2-Phenylacetamide itself is non-scheduled in most jurisdictions, its structural proximity to phenylacetic acid demands meticulous documentation. We handle end-user declarations (EUDs), dual-use screening, and customs pre-declarations under HS Code 2924299090.
Delivered in 25kg net UN-approved fiber drums with double-layer polyethylene barrier bags, or custom hermetic aluminum foil vacuum liners with food-grade molecular sieve desiccant sachets to prevent hygroscopic agglomeration and caking during sea transit.
Under our proprietary five-stage internal quality control workflow (Raw Material Testing → Reaction Process Spectroscopy → Centrifugal Crystallization Control → Analytical Release → Barcode Document Matching), every container features a batch identifier linked to our analytical cloud archive. Importers can instantly verify HPLC traces, NMR spectra, and loss-on-drying records prior to cargo acceptance.
Exploring practical synthesis pathways, catalytic conversions, and bio-industrial case studies utilizing Miaoou 2-Phenylacetamide.
In advanced pharmaceutical facilities, immobilized penicillin amidase (EC 3.5.1.11) enzymes are utilized for enantioselective cleavage and synthesis. High purity 2-phenylacetamide is consumed as an enzymatic regulator and synthetic building block. Trace impurities, specifically heavy metals (e.g., Pb, As, Cd) or unreacted nitriles exceeding 200 ppm, irrevocably deactivate expensive cross-linked enzyme aggregates (CLEAs).
By adopting Miaoou's <50 ppm low-nitrile grade 2-Phenylacetamide, downstream biotechnology clients have documented an increase of over 18% in enzyme cycle longevity across continuous packed-bed bioreactors, significantly reducing overall operational expenditure per metric ton of converted product.
Organic process research development (PR&D) teams frequently employ 2-phenylacetamide in condensation cyclizations to synthesize isoquinoline, oxazole, and pyrrole skeletons. In a recent custom pilot validation conducted for an oncology candidate precursor:
In advanced agronomic formulations, 2-phenylacetamide is utilized in the controlled synthesis of phenylacetic-family synthetic auxins. These compounds regulate root development, lateral branching, and stress tolerance in high-value horticultural crops. Our low-conductivity, salt-free grade prevents phytotoxic leaf burn when integrated into foliar bio-stimulant synthesis matrices.
Strategic engineering objectives advancing carbon neutrality, continuous microfluidics, and digital molecular verification.
Replacing traditional 5,000L glass-lined batch kettles with skid-mounted continuous microchannel reactors, reducing heat accumulation risks and achieving residence times under 90 seconds for amide formation.
Deploying third-generation recombinant Rhodococcus biocatalytic beds for ambient-temperature conversion of benzyl cyanide to phenylacetamide, reducing thermal energy footprints by 42%.
In-line Process Analytical Technology (PAT) incorporating real-time Focused Beam Reflectance Measurement (FBRM) to dynamically steer crystal nucleation, generating uniform particle size distributions tailored for high-speed automated packaging.
Complete Life Cycle Assessment (LCA) compliance with Scope 1, 2, and 3 carbon disclosures embedded directly into shipment manifests, enabling international buyers to satisfy corporate ESG regulatory quotas.
Comprehensive technical and commercial clarifications directly addressing the search intent of global procurement directors and regulatory affairs leads.
Explore our extended synthetic portfolio covering high-purity peptides, peptide analogues, and hormone reference compounds produced with verifiable analytical rigor.
Connect directly with Hebei Miaoou Technology's export engineering unit. Receive complete Certificate of Analysis (COA) records, current inventory lots, competitive tier pricing, and compliance packages within 24 hours.
