China Influenza HA (110 – 119) CAS NO.132031-50-6 Supplier, Products

Influenza HA (110-119)

Influenza HA (110-119) is a synthetic decapeptide corresponding to residues 110 through 119 (Sequence: SFERFEIFPK) of the Influenza A virus Hemagglutinin (HA) protein, supplied as a high-purity white lyophilized powder strictly for non-clinical immunological and virological research.

Characterization
It is characterized as a H-2I-Ed-restricted CD4+ T-cell epitope that plays a distinct role in modulating immune responses, specifically serving as a critical reagent for scientists studying antigen presentation, T-regulatory (Treg) cell biology, and the humoral immunity against influenza.
Intended Use
This product is specifically designed for use by immunologists, vaccine researchers, and diagnostic developers who require a reliable positive control to stimulate HA-specific T-cells, measure immune suppression or activation in assay systems, and evaluate the processing of viral envelope proteins in antigen-presenting cells.

Product Description

Technical Specifications

Item Specification
Product Name Influenza HA (110 - 119)
CAS NO. 132031-50-6
Appearance White to off-white lyophilized powder
Molecular Formula C63H90N14O16
Molecular Weight 1299.5 g/mol
Purity (RP-HPLC) ≥99.0%
Solubility Soluble in water or dilute acetic acid; insoluble in common organic solvents
Endotoxin ≤0.5 EU/mg
Biological Activity Binds stably to H-2I-Ed molecules, induces robust CD4+ T-cell proliferation, and serves as an immune modulatory epitope for studying influenza immunity and vaccine efficacy
Storage Conditions Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location Stock in USA
MOQ 1kit

1. Mechanism of Action

The biological function of Influenza HA (110-119) is defined by its specific interaction with the Major Histocompatibility Complex class II (MHC II) molecule, particularly the H-2I-Ed allele, forming a peptide-MHC complex that is recognized by the T-cell receptor (TCR) on CD4+ helper T-cells. Unlike internal viral proteins that typically trigger MHC I restricted cytotoxic responses, this extracellular HA-derived fragment is processed and presented on the surface of antigen-presenting cells (APCs) like dendritic cells to engage the CD4+ T-cell compartment. Notably, this specific epitope possesses the unique capacity to selectively stimulate the proliferation and activation of CD4+ CD25+ Regulatory T cells (Tregs), which in turn exert suppressive functions on effector T-cell responses, thereby influencing the fine-tuning of the overall immune balance and preventing excessive immunopathology during viral encounters.
Influenza HA (110 – 119) CAS NO.132031-50-6

2. Product Indications

Influenza HA (110 – 119) CAS NO.132031-50-6
This product is indicated for preclinical research applications targeting professionals in viral immunology, autoimmune research, and vaccine technology who are investigating the nuances of CD4+ T-cell epitope mapping and immune regulation. It is particularly suitable for researchers utilizing the peptide to pulse bone marrow-derived dendritic cells or splenocytes to study antigen presentation dynamics, to isolate and expand influenza-specific T-cell lines, or to model immune tolerance mechanisms in vitro. Furthermore, it is applicable for scientists conducting structure-activity relationship studies on HA epitopes, serving as a standard for ELISA coating to detect HA-specific antibodies, and for pharmacologists testing immunomodulatory drugs that aim to manipulate Treg function or Th cell differentiation, all within controlled laboratory environments.

3. Clinical Efficacy of Product

As a raw synthetic peptide reagent not formulated for human therapeutic or diagnostic administration, Influenza HA (110-119) does not possess approved clinical efficacy, yet it is fundamental in elucidating immune correlates validated in extensive preclinical and clinical immunological studies. Experimental data confirm that HA-specific CD4+ T-cells recognize this epitope across different influenza strains, and that analogs of this peptide can enhance T-cell activation by modifying dendritic cell antigen presentation functions or activate Treg suppressor mechanisms. Additionally, research highlights its utility in dissecting why certain HA epitopes induce tolerance versus immunity, underscing its value as a benchmark tool for measuring CD4+ T-cell memory, designing adjuvanted vaccines that optimize T-helper responses, and developing peptide-based immunotherapies for autoimmune conditions rather than acting as a standalone clinical treatment.

4. Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications. Our production partners all employ GMP-compliant production systems and possess standardized quality control processes.
  • A rigorous quality management system
  • Batch traceability and stability data
  • Professional laboratory testing and validation
  • Compliance with international trade standards
Influenza HA (110 – 119) CAS NO.132031-50-6

5. Delivery & Shipping

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation. We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight. We primarily use DHL, FedEx, UPS, and TNT because of their global reliability and speed.

Influenza HA (110 – 119) CAS NO.132031-50-6

Frequently Asked Questions

What is the purity and endotoxin level of Influenza HA (110 - 119)?

The peptide is tested via RP-HPLC with a guaranteed purity of ≥99.0% and features an ultra-low endotoxin level of ≤0.5 EU/mg, making it suitable for delicate immunological assays.

How should this peptide be properly dissolved?

Influenza HA (110 - 119) is soluble in water or dilute acetic acid. It is insoluble in common organic solvents.

What are the suggested storage parameters to maintain stability?

It should be kept at -20°C in a dry, dark, and well-sealed container. Ensure repeated freeze-thaw cycles are avoided to preserve biological activity and structural integrity.

Is this product suitable for in vivo human clinical treatments?

No, Influenza HA (110 - 119) is supplied as a raw synthetic peptide reagent dedicated strictly to preclinical research, laboratory assays, and in vitro immunological studies.

What carriers and transit terms are offered for dispatch?

We use international air freight through primary carriers like DHL, FedEx, UPS, and TNT, packaged inside protective materials with custom packing options available upon request.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry.

Hot Tags: T-cell Epitope, Synthetic Peptide, Hemagglutinin, Influenza A, Immunology, Vaccine Research, Treg, MHC Class II, SFERFEIFPK, Immune Regulation, Antigen Presentation, CD4+ T-cell.

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