Factory-verified reference standards, bioactive compounds, and pharmaceutical building blocks manufactured in certified cGMP facilities with complete batch provenance.
4'-Methylpropiophenone (synonyms: p-methylpropiophenone, 1-(4-methylphenyl)propan-1-one) is a key aromatic intermediate integral to precision medicinal chemistry, organocatalytic reactions, and functional polymer production.
| Analytical Parameter | Specification Threshold | Typical Factory Lot Analysis | Test Methodology |
|---|---|---|---|
| CAS Number | 5337-93-9 | Confirmed Identity | CAS Registry Cross-Reference |
| IUPAC Nomenclature | 1-(4-methylphenyl)propan-1-one | 1-(4-methylphenyl)propan-1-one | Structure Verification (1H-NMR) |
| Physical Appearance | Colorless to pale yellowish liquid / crystal | Clear pale yellow liquid (25°C) | Visual & Optical Photometry |
| Chemical Formula & MW | C10H12O | 148.20 g/mol | Matches Theoretical Distribution | High-Res Mass Spectrometry (HRMS) |
| Assay Purity (GC-FID) | ≥ 99.0% minimum | 99.68% - 99.85% | Capillary Gas Chromatography |
| Boiling Point | 238 - 239 °C at 760 mmHg | 238.4 °C | Differential Scanning Calorimetry (DSC) |
| Density & Refractive Index | 0.993 g/cm³ | n20/D 1.528 | 0.992 g/cm³ | 1.5276 | Pycnometer / Abbe Refractometer |
| Residue on Ignition | ≤ 0.1% max | 0.02% | Thermogravimetric Furnace (USP ⟨281⟩) |
| Quality Release Verification | GMP & ISO 9001 Compliant | ✓ Batch COA Certified | Multi-Spectra Release Protocol |
How global procurement heads, pharmaceutical synthesis directors, and industrial material formulators harness high-purity methylpropiophenone across regulated sectors.
Serves as a pivotal structural precursor for synthesizing central nervous system regulators, cardiovascular therapeutics, and anti-inflammatory compounds. Its para-methyl substituent provides an ideal electronic profile for selective alpha-bromination, asymmetric ketonic reductions, and reductive aminations in multi-step commercial drug synthesis.
Essential building block for high-efficiency Norrish Type I and Type II photoinitiators utilized in UV-curable coatings, industrial adhesives, and stereolithography 3D-printing resins. The alkyl-aryl ketone chromophore yields superior triplet-state quantum efficiency under 365nm and 395nm LED radiation bands.
Widely integrated into niche flavor and fragrance formulation pipelines. Due to its clean, floral-fruity undertone and balsamic stability, derivative esters and hydrogenated carbinols are utilized in personal care products, detergent base fragrances, and fixative carriers requiring high vapor pressure stability.
Employed in the tailored synthesis of conjugated polymers and liquid crystal monomers. The rigid planar geometry imparted by the 4-methyl substituted phenone core optimizes dipole moment alignments in non-linear optical (NLO) waveguide films and electroluminescent display substrates.
A key intermediate in developing novel crop-protection fungicides, selective herbicides, and botanical growth elicitors. The functional carbonyl center allows seamless heterocyclic cyclization into triazole, imidazole, and oxazole rings that demonstrate potent antifungal bioassays against phytopathogens.
Universities, global CROs, and pilot chemistry facilities utilize our batch-characterized 5337-93-9 raw material for benchmark catalysis research, C-H functionalization libraries, stereoselective organoboron addition trials, and scalable process optimization campaigns.
Advancing fine chemical manufacturing through transition-metal-free catalytic engineering, microchannel continuous crystallization, and real-time Process Analytical Technology (PAT).
Toluene and propionyl chloride / propionic anhydride are metered through Hastelloy-C microreactors under continuous pressure. Precision residence time (≤ 18 seconds) eliminates thermal hotspots, driving para-isomer regioselectivity past 99.1%.
Transitioning away from corrosive, aqueous-generating stoichiometric AlCl3 catalysts to recyclable H-Beta zeolites and ionic liquid matrices. Drastically lowers the E-factor (waste-to-product ratio) from 4.8 down to 0.62.
High-vacuum multi-plate distillation separates trace ortho-isomers (2-methylpropiophenone) and unreacted aromatics. Continuous monitoring via in-line Raman and FTIR spectroscopy ensures real-time assay conformance.
Purified product undergoes sub-ambient nitrogen purging to prevent oxidative discoloration. Packaged in fluorinated HDPE drums or ISO tank containers with tamper-evident, nitrogen-blanketed hermetic seals.
How raw material integration, clustered production ecosystems, and dedicated hazardous freight lanes protect global buyers from supply disruptions.
Our chemical manufacturing facilities are directly piped to world-scale refining corridors across Hebei, Shandong, and Jiangsu chemical industrial parks. Guaranteed pipeline access to high-purity toluene and propionic acid insulates contracts from spot-market price shocks and feedstock shortages.
Our automated synthesis bays support parallel multi-tonne batch campaigns alongside dedicated continuous flow units. Whether procuring 25 kg pilot validation drums or recurring 40-foot full container loads (FCL), lead times remain reliably between 5 and 12 business days.
Seamless coordination through Tianjin, Qingdao, and Shanghai bonded terminals. We maintain fully compliant maritime Dangerous Goods (DG) packing declarations, UN-certified packaging ratings, and direct booking allocations with Tier-1 shipping alliances to guarantee zero port-of-origin delays.
We eliminate international procurement risks through audited testing data, exhaustive regulatory dossier provisioning, and strict adherence to destination-market laws.
Every outgoing batch is released with a lot-specific Certificate of Analysis featuring calibrated GC-FID chromatograms, 1H/13C-NMR spectra, and Karl Fischer moisture titrations. Fully translated, 16-section Safety Data Sheets (GHS/OSHA/CLP compliant) accompany all orders.
Assisting EU importers via Only Representative (OR) coverage, Late REACH Pre-registrations, and TSCA compliance documentation for US buyers. We maintain clear customs declarations confirming 5337-93-9's standard industrial classification under HS Code 2914.39.00.
To uphold ultimate buyer confidence, our quality management framework welcomes pre-shipment sampling and testing by independent international auditing houses such as SGS, Intertek, or Eurofins upon commercial client request.
Direct answers addressing technical specifications, logistics, storage conditions, and international customs clearance for CAS 5337-93-9.
Our standard commercial manufacturing specification guarantees ≥ 99.0% purity by GC-FID. Our specialized continuous flow distillation unit consistently achieves ultra-high purity grades between 99.5% and 99.85%, with individual unknown impurities strictly capped below 0.10% and moisture under 0.05%.
We supply 5337-93-9 in 25 kg UN-rated fluorinated polyethylene carboys, 200 kg coated steel/HDPE drums, and 1,000 kg IBC tote containers. For recurring bulk accounts, dedicated 20-24 MT ISO tank containers are dispatched with nitrogen blanketing to prevent moisture and oxidation during transit.
Store in a cool, well-ventilated, dry warehouse away from direct sunlight, open flames, and incompatible oxidizing agents. Recommended storage temperature is between 2°C and 8°C for long-term inventory, or below 25°C for sealed, nitrogen-blanketed operational stock. The product maintains a guaranteed shelf-life of 24 months.
Yes. In addition to supplying neat CAS 5337-93-9, our R&D synthesis labs perform custom derivative manufacturing, such as selective alpha-halogenation (e.g., 2-bromo-4'-methylpropiophenone, CAS 1451-82-7) or asymmetric catalytic hydrogenations to produce chiral carbinol precursors under strict non-disclosure agreements (NDA).
Our freight operations department possesses over 15 years of experience in fine chemical export handling. We generate full Dangerous Goods Declaration (DGD) dossiers, certified MSDS in target languages, packing inspection reports, and certificate of origin (Form A / Form E / CO) to ensure frictionless port-to-port and DDP transfers.
Commercial MOQ starts at 25 kg (single drum). For enterprise laboratory evaluation, analytical method qualification, and customer verification trials, we supply 100g, 500g, and 1 kg sample aliquots dispatched via air express courier within 24 to 48 hours of confirmation, accompanied by lot-specific COA data.
Browse our extensive inventory of high-purity research compounds, endocrine agonists, and pharmaceutical intermediates available for commercial export.
