Directly sourced from advanced cGMP-aligned synthesis lines. Each reference compound and bulk active pharmaceutical intermediate is delivered with verifiable HPLC chromatograms, mass spectrometry profiles, and complete export documentation.
Cas 2446-23-3, chemically designated as 4-Chlorodehydromethyltestosterone (oral turinabol derivative), represents a chlorinated synthetic steroid scaffold of immense significance in endocrinological research, reference standard development, and targeted androgen receptor binding assays.
CAS 2446-23-3 is characterized by the addition of a chloro-group at the 4-position combined with a double bond between carbon positions 1 and 2 of the testosterone steroid core. This specific substitution fundamentally alters metabolic breakdown paths, prevents aromatization into estrogenic metabolites, and provides high structural stability against hepatic enzymatic degradation.
For chemical procurement teams, contract research organizations (CROs), and analytical standard manufacturers, obtaining an unadulterated product with HPLC purity ≥ 99.0% is non-negotiable. Substandard synthesis often introduces hazardous chlorinated regioisomers, residual metallic coupling agents, and unreacted solvent fractions that skew analytical calibration curves and ruin in-vitro bioassays.
Hebei Miaoou Technology Co., Ltd. (operating since 2010) enforces rigorous batch trace protocols. Our facilities leverage automated multi-stage solvent crystallization, vacuum desiccation, and continuous process analytical technology (PAT) to ensure batch-to-batch consistency that strictly fulfills international fine-chemical standards.
| Analytical Parameter | Standard Specification (USP/EP Grade) |
|---|---|
| IUPAC Name | (4-chloro-17β-hydroxy-17α-methylandrosta-1,4-dien-3-one) |
| CAS Registry Number | 2446-23-3 |
| Molecular Formula / Weight | C20H27ClO2 | 334.88 g/mol |
| Physical Appearance | White to pale off-white crystalline powder |
| Chromatographic Purity (HPLC) | ≥ 99.0% (Single Impurity ≤ 0.5%) |
| Melting Point Range | 162°C – 167°C (Sharp narrow thermal band) |
| Loss on Drying (LOD) | ≤ 0.50% w/w |
| Heavy Metal Residues (ICP-MS) | ≤ 10 ppm total (Pb, As, Cd, Hg ≤ 1 ppm each) |
The international landscape for fine chemical APIs, steroid reference materials, and custom synthesis intermediates is undergoing massive restructuring. Shifts toward strict spectral verification, zero-defect quality systems, and ESG-compliant synthesis dictate vendor selection.
Forensic toxicology institutions, WADA-accredited anti-doping laboratories, and academic pharmacology programs are experiencing a 34% CAGR in reference standard procurement. CAS 2446-23-3 serves as a vital diagnostic calibration agent for tandem mass spectrometry (LC-MS/MS) and GC-MS metabolic tracking algorithms.
Western and Asia-Pacific corporate buyers are systematically bypassing opaque multi-tier trading brokers. Procurement directors demand first-party factory transparency, complete audit trails from starting materials (androstenedione derivatives) to final recrystallized cakes, and validated batch stability data.
Traditional steroid halogenation utilized hazardous reagents yielding heavy organic effluents. Contemporary Class-A Chinese manufacturers utilize continuous-flow microreactors and catalytic chlorination, decreasing carbon intensity by 45% while eliminating harmful cross-contamination hazards.
How digital automation, distributed DCS synthesis monitoring, and automated analytical QC eliminate supply bottlenecks, stabilize international chemical pricing, and guarantee pharmaceutical-tier consistency.
Microchannel reactor systems provide precise millisecond control over exothermic dehydrogenation and chlorination reactions, preventing thermal degradation and eliminating off-target isomeric byproduct formations.
Isolated crystallization cakes undergo programmatic low-temperature drying under ultra-high vacuum (< 0.05 mbar), eliminating solvent entrapment and guaranteeing moisture content consistently ≤ 0.35%.
Real-time Fourier Transform Infrared (FTIR) probes and optical density meters directly monitor reaction vessels, automatically arresting reaction cycles at peak conversion before any degradation phase begins.
Strategic vertical integration with upstream steroid precursor plants ensures stable inventory cushions exceeding 5,000 kg, immunizing international partners against raw ingredient market fluctuations.
A rigorous five-stage qualification matrix designed for pharmaceutical QA leads, analytical research directors, and international chemical purchasing managers to completely de-risk raw material sourcing.
Every batch must demonstrate a clean baseline using a reverse-phase C18 column (e.g., 250 × 4.6 mm, 5 μm) at 245 nm UV detection. Overall area normalization purity must certify at ≥ 99.0% with zero unidentified single impurities exceeding 0.3%.
High-resolution electrospray ionization mass spectrometry (ESI-MS) confirms the exact monoisotopic [M+H]+ and [M+Na]+ adducts at m/z 335.18 and 357.16, proving absolute structural identity without fragment mismatch.
1H-NMR (400/600 MHz in CDCl3) rigorously maps the chlorine substitution position at C4, verifying chemical shifts distinct from standard Dianabol or Clostebol analogues and eliminating isomer ambiguity.
Headspace Gas Chromatography (GC) confirms compliance with USP <467> Class 2/3 limits (methanol < 3000 ppm, acetonitrile < 410 ppm, ethanol < 5000 ppm). ICP-MS confirms heavy metal thresholds below 10 ppm.
Procurement Notice: Hebei Miaoou Technology Co., Ltd. issues genuine Certificates of Analysis (COA) cross-stamped with specific batch production IDs. Blind sample splits for independent accredited laboratory re-testing (SGS, Intertek, or institutional labs) are unconditionally supported on all commercial procurement volumes.
Cas 2446-23-3 serves as an indispensable compound across distinct scientific research disciplines, medical bioengineering research, and global analytical regulatory sectors.
Utilized globally by regulatory bodies and forensic crime labs as high-purity analytical reference material for calibrating triple-quadrupole gas and liquid chromatography systems targeting long-term urinary metabolites (such as 4-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5α-androst-13-en-3α-ol).
Academic medical research divisions utilize high-grade CAS 2446-23-3 to study selective androgen receptor modulations (SARM-like actions), investigating tissue selectivity indices between myotropic muscle hypertrophy and androgenic prostate stimulation without aromatase activity.
Used as a core substrate in human liver microsome (HLM) and recombinant cytochrome P450 (CYP3A4/5) enzymatic assays to explore hepatic phase I and phase II glucuronidation pathways, providing critical baseline data for modern therapeutic xenobiotic development.
Clear, direct answers regarding Cas 2446-23-3 analytical verification, minimum order quantities, stability handling, and international customs clearance procedures.
Every delivery is accompanied by a batch-matched Certificate of Analysis (COA) with raw HPLC integration reports, Electrospray Mass Spectrometry (MS) identity graphs, 1H-NMR spectra, and an updated Safety Data Sheet (SDS / MSDS). Custom proforma invoices and packaging declarations match your procurement requirements exactly.
Unchlorinated intermediates (such as methandrostenolone) present serious regulatory and analytical risks. Our synthesis routes feature high-efficiency microreactor halogenation followed by high-resolution preparative chromatography, ensuring non-detectable precursor limits (< 0.05% LOD via sensitive HPLC-UV).
Standard packaging utilizes double food-grade polyethylene interior heat-sealed bags enclosed in vacuum-evacuated aluminum foil pouches, packed within fiberboard drums (1kg, 5kg, 25kg formats). When stored protected from light at ≤ 20°C in a cool, dry desiccated atmosphere, stability is guaranteed for 36 months.
Our global logistics division has over 16 years of chemical forwarding experience across North America, Europe, and Asia-Pacific. We provide optimized harmonized system (HS) classification, discreet multi-layer security packaging, full export declarations, and end-to-end tracked transit with 100% customs clearance logistics options.
For institutional laboratory R&D and reference testing, sample validation quantities start at 10g to 50g. For industrial commercial distribution and manufacturing clients, supply volume tiers range seamlessly up to metric ton scale with dedicated batch synthesis reserving.
We support multiple verified B2B transactional methods including Telegraphic Transfer (T/T), international escrow services, and customized documentary letters of credit for qualified bulk repeat contract partners, providing total compliance transparency for enterprise procurement departments.
Browse our extended factory supply portfolio. All compounds are synthesized in state-of-the-art facilities under strict environmental controls, backed by batch traceability and international export clearance.
