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| Item | Specification |
|---|---|
| Product Name | Fibrinolysis Inhibitng Factor |
| CAS NO. | 67869-62-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C18H31N7O5 |
| Molecular Weight | 425.49 g/mol |
| Purity (RP-HPLC) | ≥99.0% |
| Solubility | Freely soluble in distilled water (≥ 50 mg/mL); also soluble in DMSO or dilute acetic acid; reconstitute to desired concentration in buffer or cell-free system as needed |
| Endotoxin | ≤0.001 EU/mg |
| Biological Activity | Binds to the "a" polymerization pocket (D-domain hole) of fibrinogen/fibrin with higher affinity than native fibrin α-chain knob; blocks fibrin monomer "knob-hole" assembly, inhibits fibrin polymerization and Factor XIIIa-mediated crosslinking; GPRP–fibrinogen complex shows increased resistance to plasmin degradation |
| Storage Conditions | Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1kit |
This peptide competitively binds to the "a" polymerization pocket (D-domain hole) within the β- and γ-chains of fibrinogen/fibrin with higher affinity than the native fibrin α-chain knob, thereby occupying the polymerization site and sterically blocking the normal "knob-hole" interaction required for fibrin monomer assembly. By forming a stable GPRP–fibrinogen complex, it prevents further fibrin fiber formation and inhibits Factor XIIIa-mediated crosslinking of fibrin chains, while the resulting complex exhibits increased resistance to plasmin-induced proteolysis, making it a valuable modulator of the fibrinolytic cascade in mechanistic studies.
This product is intended exclusively for laboratory research use and is suitable for universities, hospitals, and biopharmaceutical R&D laboratories investigating hemostasis, thrombosis mechanisms, and fibrinolytic pathway regulation. Typical applications include fibrin polymerization inhibition assays, thromboelastography (TEG) calibration controls, preparation of thrombin-degranulated platelet suspensions (to prevent fibrin entrapment), and as a positive control in coagulation factor XIIIa activity or plasmin resistance studies using purified proteins or citrated human plasma.
Although this peptide is not a drug and has no approved clinical application, published preclinical and ex vivo studies demonstrate that GPRP effectively inhibits fibrin clot formation and alters thromboelastographic parameters toward a hypocoagulative state in human plasma models, and its ability to block fibrin assembly has been extensively validated as a benchmark for understanding physiologic fibrin stabilization and pathologic hyperfibrinolysis. The term "efficacy" here refers strictly to its proven utility in reproducing and interrupting fibrin polymerization in validated research models, supporting the development of next-generation antifibrinolytic therapeutics and coagulation diagnostic assays.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems. Each batch comes with COA, HPLC purity report, and MS chromatograms.
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation. Custom packaging available upon request.
Main Method: International Air Freight (DHL, FedEx, UPS, TNT). Ensures the fastest transit time and minimizes environmental impact.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry.
It functions by competitively binding to the polymerization pocket of fibrinogen/fibrin, effectively blocking knob-hole assembly, inhibiting fibrin polymerization, and preventing Factor XIIIa-mediated crosslinking.
No, this compound is strictly For Research Use Only (RUO). It is intended for laboratory research purposes and is not approved for human or veterinary diagnostic or therapeutic applications.
The product should be stored at -20°C in a dry, dark, and tightly sealed container. To maintain optimal biochemical stability, avoid repeated freeze-thaw cycles.
It is freely soluble in distilled water at concentrations ≥ 50 mg/mL, and can also be dissolved in DMSO or dilute acetic acid before reconstitution into relevant assay buffers.
Every batch manufactured under GMP-compliant standards is accompanied by a Certificate of Analysis (COA), an RP-HPLC purity analytical report verifying ≥99.0% purity, and MS chromatogram data.
Stock is maintained in the USA for rapid availability, and international shipments are expedited via premium air freight carriers such as DHL, FedEx, UPS, and TNT in secure, protective packaging.
