| Item |
Specification |
| Product Name |
Retatrutide |
| CAS NO. |
2381089-83-2 |
| Appearance |
White to off-white lyophilized powder |
| Molecular Formula |
C221H342N46O68 |
| Molecular Weight |
4731.33 g/mol |
| Purity (RP-HPLC) |
≥98.0% |
| Solubility |
Soluble in water or 0.9% saline solution; compatible with standard buffers |
| Endotoxin |
≤ 0.1 EU/mg |
| Biological Activity |
Potent agonist for GLP-1, GIP, and glucagon receptors; promotes weight loss & glucose control |
| Storage Conditions |
Store at 2–8°C protected from light; avoid repeated freeze-thaw cycles |
| Stock Location |
Stock in USA |
| MOQ |
1g |
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1. MECHANISM OF ACTION
The mechanism of action of Retatrutide is characterized by its unique triple-agonist profile, which integrates the effects of three key metabolic hormones. By activating GLP-1 receptors, it enhances insulin secretion and suppresses glucagon release in a glucose-dependent manner while slowing gastric emptying to increase satiety; through GIP receptor agonism, it improves insulin sensitivity and may potentiate the effects on adipose tissue; and critically, by activating the glucagon receptor, it increases energy expenditure and promotes lipolysis, thereby creating a synergistic effect that not only reduces appetite but also actively burns stored fat.
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2. PRODUCT INDICATIONS
Retatrutide is indicated for the treatment of adults with obesity (BMI ≥30 kg/m²) or overweight (BMI ≥27 kg/m²) with at least one weight-related comorbidity, as well as for the management of type 2 diabetes mellitus. It is particularly suitable for patients seeking substantial weight loss beyond what is typically achievable with lifestyle modifications or first-line pharmacotherapies, including those who may be considering bariatric surgery but prefer a non-surgical alternative, and individuals requiring robust glycemic control alongside significant body weight reduction.
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3. CLINICAL EFFICACY OF PRODUCT
Clinical trial data, notably from the Phase 2 TRIUMPH study, demonstrate that Retatrutide achieves unprecedented levels of weight reduction, with up to 24.2% mean body weight loss at 48 weeks at the 12 mg dose, and over 30% weight loss observed in a significant proportion of participants at 72 weeks. For glycemic control, it achieved HbA1c reductions of up to 2.02%, significantly outperforming active comparators like dulaglutide. Furthermore, the product has shown efficacy in reducing liver fat content and improving cardiometabolic markers such as blood pressure and lipids, establishing it as a potent agent for comprehensive metabolic health.
4. Certificate & Quality Management
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
✔ 1. A rigorous quality management system
✔ 2. Batch traceability and stability data
✔ 3. Professional laboratory testing and validation
✔ 4. Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5. DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation. We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight. We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity.
HotTags: Retatrutide, TripleAgonist, ObesityTreatment, Type2Diabetes, WeightLossJourney, GLP1Agonist, MetabolicHealth, EliLilly, ClinicalTrials, NewDrug, FatLoss, IncretinTherapy Supplier, Manufacturer, Bulk order, Pharmaceutical.
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Retatrutide FAQ & Insights
Q
Does Retatrutide Actually Burn Fat?
Retatrutide is an experimental medication being studied for obesity and metabolic disease. It activates three key hormone receptors: GLP-1, GIP, and glucagon. By stimulating GLP-1 and GIP pathways—similar to drugs like Tirzepatide—it significantly reduces hunger and food intake. At the same time, its glucagon receptor activity may slightly increase energy expenditure, meaning the body uses more calories at rest. This combination creates a sustained calorie deficit, which leads to fat loss. Clinical studies have shown that people taking retatrutide can lose a substantial percentage of their body weight, much of which comes from fat mass rather than muscle.
Q
What are the Primary Benefits of Retatrutide?
One of the most notable benefits is substantial weight loss, often exceeding what has been observed with earlier medications. Beyond weight management, retatrutide has demonstrated improvements in metabolic health, such as lowering blood glucose levels and improving insulin sensitivity. Another important benefit is its potential impact on cardiovascular risk factors and reducing liver fat, which may be beneficial for conditions like nonalcoholic fatty liver disease.
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How Can You Obtain Retatrutide?
Retatrutide is still an investigational drug, so you generally cannot obtain it through standard prescriptions or pharmacies at this time. The primary way to access retatrutide right now is through participation in clinical trials. It is important to be cautious about online sources claiming to sell retatrutide; any products marketed directly to consumers are likely unregulated and may be unsafe. The safest path to access is through properly conducted clinical research under medical supervision.
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What Makes Retatrutide Different From Previous Incretin Therapies?
Unlike single GLP-1 agonists (e.g., Semaglutide) or dual GLP-1/GIP agonists (e.g., Tirzepatide), Retatrutide targets three distinct metabolic pathways: GLP-1, GIP, and glucagon. This triple mechanism not only controls appetite and insulin response but additionally accelerates metabolic rate and promotes lipolysis directly via glucagon signaling.
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What is the Recommended Storage Condition for Retatrutide Lyophilized Powder?
Retatrutide lyophilized powder should be stored under refrigerated conditions at 2–8°C, fully protected from direct light exposure. Repeated freeze-thaw cycles must be strictly avoided to ensure long-term stability, biological activity, and product purity.
