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2-Bromo-4-Methylpropiophenone (commonly referred to as 2-bromo-1-(4-methylphenyl)propan-1-one, CAS No. 1451-82-7) serves as a cornerstone electrophilic intermediate in advanced organic synthesis, aromatic functionalization, and commercial pharmaceutical chemistry.
| Analytical Parameter | Guaranteed Technical Specification | Laboratory Test Methodology | Commercial Batch Validation |
|---|---|---|---|
| IUPAC Chemical Nomenclature | 2-bromo-1-(4-methylphenyl)propan-1-one | IUPAC Standard Rules | Structure Validated by 1H-NMR & 13C-NMR |
| CAS Registry Number | 1451-82-7 | CAS Verification Standard | Traceable Chemical Substance Index |
| Molecular Formula & Weight | C10H11BrO | 227.10 g/mol | High-Resolution Mass Spectrometry (HR-MS) | Conforms to monoisotopic exact mass (226.00 g/mol) |
| Physical State & Appearance | White to light-cream crystalline powder / solid | Visual / Photometric Inspection | Uniform crystalline morphology, lump-free |
| Assay / Chromatographic Purity | ≥99.2% (Area Normalization) | Reverse-Phase HPLC (C18, UV 254 nm) | Batch range 99.35% – 99.82% |
| Melting Point Range | 74.0 °C to 77.0 °C | Capillary Melting Point Apparatus (Pharmacopeia method) | Sharp melting transition (±0.8 °C) |
| Isomeric Impurities (Ortho/Meta) | ≤0.20% combined total | Gas Chromatography Flame Ionization (GC-FID) | Typically <0.08% via regional Friedel-Crafts control |
| Loss on Drying / Moisture | ≤0.30% w/w | Karl Fischer Coulometric Titration | Mean batch moisture <0.12% w/w |
| Residual Solvents | Meets USP <467> / ICH Q3C limits (DCM <600ppm, Tol <890ppm) | Headspace Gas Chromatography (HS-GC-MS) | Non-detectable or negligible residual trace |
In an era of intensified regulatory scrutiny, environmental shutdowns, and logistical bottlenecks, enterprise chemical procurement teams require verified direct-from-manufacturer partnerships that guarantee batch homogeneity, pricing stability, and regulatory security.
Sudden disruptions in fine intermediate synthesis cascades can idle multi-million-dollar downstream active pharmaceutical ingredient (API) facilities. We operate continuous dedicated flow and batch reactor arrays capable of producing 50 metric tons annually, maintaining safety stocks that shield our contract partners from regional feedstock shortages and international ocean freight delays.
Unregulated broker networks often introduce off-spec 2-bromo-4-methylpropiophenone tainted with reactive alpha,alpha-dibrominated byproducts or corrosive elemental bromine traces. Every container leaving our plant features tamper-evident holographic barrier seals cross-referenced with cloud-verifiable HPLC chromatograms and batch-specific analytical passports.
Pharmaceutical quality control officers require exhaustive documentation for supplier qualification audits. We furnish full documentation packages including SDS (Safety Data Sheets compliant with GHS 2024), dynamic Certificates of Analysis (COA), BSE/TSE declaration statements, elemental impurity statements (ICH Q3D), and country-of-origin notarization.
The catalytic synthesis of 2-bromo-4-methylpropiophenone demands meticulous thermodynamic regulation. The reaction pathway centers on the regioselective alpha-bromination of 4-methylpropiophenone (CAS 5337-72-4) under controlled kinetic parameters.
Direct elemental bromination with liquid $Br_2$ carries substantial risks of runaway exotherms and the formation of destructive side products, particularly 2,2-dibromo-4-methylpropiophenone and aromatic ring-brominated isomers. Our manufacturing architecture utilizes continuous flow micro-channel reactors paired with in-line spectrophotometric sensors. By introducing hydrobromic acid scavengers and non-polar, eco-friendly solvent systems (such as high-purity methyl tert-butyl ether or recoverable dichloroethane fractions), we achieve exceptional conversion rates exceeding 98.5% while suppressing unreacted ketone precursors to below 0.3%.
Spectroscopic assay of starting 4-methylpropiophenone to confirm the absolute absence of ortho/meta isomers prior to halogenation feeding.
Continuous-feed addition of bromine under cryogenic-to-ambient thermal regulation (15°C – 22°C) with in-situ quenching to prevent over-halogenation.
Neutralizing acidic wash cycles using food-grade sodium bicarbonate buffers followed by deionized water washes to completely eliminate trace bromides.
Thermal solvent-antisolvent recrystallization yields large, uniform, highly stable crystals, stripping lingering trace mother liquor.
Low-temperature vacuum drying under inert dry nitrogen blankets prevents oxidative degradation and guarantees moisture <0.2%.
Because of its highly labile alpha-bromine atom adjacent to a resonance-stabilized aromatic ketone carbonyl, 2-bromo-4-methylpropiophenone exhibits versatile reactivity across nucleophilic substitutions, reductive aminations, and heterocyclic cyclizations.
Serves as a pivotal structural synthon in medicinal chemistry pipelines for the synthesis of central nervous system (CNS) modulators, cardiovascular agents, and anti-inflammatory compounds. The molecule's clean substitution profile allows high-yield amine couplings without extensive by-product purification.
In specialty materials engineering, derivatives of 4-methylpropiophenone act as rapid-curing alpha-cleavage photoinitiators for UV-curable industrial resins, specialized optical adhesives, microelectronic circuit encapsulants, and precision stereolithography polymers.
Academic laboratories and corporate discovery teams utilize enantioselective reduction platforms (such as CBS oxazaborolidine reductions or asymmetric transfer hydrogenations) on 2-bromo-4-methylpropiophenone to generate chiral halohydrins and enantioenriched epoxides with over 99% enantiomeric excess (ee).
Cross-border chemical supply chains require rigorous adherence to international commerce treaties, hazardous materials transport classifications, and multi-jurisdictional precursor monitoring policies.
Accurate customs declarations utilizing standard HS Code 2914.79.00 (Halogenated, sulfonated, nitrated, or nitrosated derivatives of ketones). We provide verified commercial invoices, packing lists, and export permits preventing port seizures.
In accordance with global precursor diversion prevention protocols (including EU Precursor Regulations and UN INCB frameworks), transactions are validated via rigorous Know-Your-Customer (KYC) compliance checks and valid commercial licenses.
Shipped in high-density polyethylene (HDPE) drums lined with double anti-static vacuum-sealed fluorinated barrier bags. Packaged in UN-approved UN 2811 / PG III certified cartons with complete Hazmat labeling and documentation.
While 2-bromo-4-methylpropiophenone remains solid at standard room temperature (melting point ~75°C), long-distance ocean voyages through equatorial climates can induce trace sublimation. We offer insulated, temperature-monitored refrigerated container shipping.
Direct technical answers addressing purity verification, regulatory restrictions, ordering logistics, and custom synthesis parameters.
Every commercial batch is accompanied by an authenticated Certificate of Analysis (COA) containing exact batch number, date of manufacture, melting point confirmation, quantitative Karl Fischer moisture titration, and high-resolution Reverse-Phase HPLC chromatograms with UV peak integration data. 1H-NMR, 13C-NMR, and GC-MS fragmentation profiles are available upon request for quality dossier reviews.
Our plant utilizes stoichiometric kinetic control via continuous-feed micro-channel reactors rather than indiscriminate bulk-pot halogenation. By carefully dosing elemental bromine at low temperature in the presence of mild acid acceptors, the reaction stops precisely at the mono-brominated species, keeping 2,2-dibromo-4-methylpropiophenone impurities strictly below 0.15% w/w.
Standard packaging begins at 1 kg foil bags for exploratory lab evaluations and scale-up trials. For industrial commercial production, our standard container formats are 25 kg UN-rated fiber or HDPE drums with dual polyethylene vacuum liners, and 500 kg palletized super-sacks for continuous high-volume manufacturing facilities.
2-Bromo-4-Methylpropiophenone is thermally and chemically stable when stored between 2°C and 8°C under an inert nitrogen blanket away from direct light, strong nucleophiles, and basic aqueous conditions. When maintained in unopened original factory packaging, the compound exhibits an experimentally validated shelf life of 24 months without loss of chromatographic purity.
Yes. Our in-house R&D and chemical engineering teams routinely support contract synthesis for related halogenated propiophenone analogues, customized particle size distributions (micronized powders), specialized crystal habit optimization, or strict limits on specific residual heavy metals and organic solvents under custom quality agreements.
We work exclusively with certified tier-1 dangerous goods chemical freight forwarders. Prior to cargo release, our compliance division verifies all HS codes, generates GHS-compliant Safety Data Sheets in 14 languages, prepares formal commercial invoices, and ensures proper Toxic Substances Control Act (TSCA) or REACH pre-registration credentials match border agency requirements.
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