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Inquire Specification4-Aminoacetophenone (CAS Number: 99-92-3), also recognized in chemical nomenclature as p-aminoacetophenone, 1-(4-aminophenyl)ethan-1-one, or 4-acetylaniline, serves as a cornerstone organic intermediate across global pharmaceutical, agrochemical, and specialty dye manufacturing sectors. Characterized by its aromatic amine structure conjugated with an acetyl group, this bifunctional aromatic compound demonstrates exceptional reactivity in diazotization, condensation, electrophilic substitution, and heterocyclic synthesis reactions.
For global procurement managers, pharmaceutical synthesis directors, and industrial chemical buyers, evaluating vendors when looking to buy 4-Aminoacetophenone manufacturers & factories requires an exhaustive audit of chemical purity, structural isomer control, heavy metal contamination thresholds, and supply chain scalability. Industrial synthesis primarily utilizes catalytic reduction of 4-nitroacetophenone or acetylative pathways starting from aniline derivatives. The physical appearance of high-purity grade material is typically a pale yellow to light brown crystalline powder, with a defined melting point range of 104°C to 108°C and an HPLC purity assay exceeding 99.5% for pharmaceutical API building-block applications.
Information Gain Key Takeaway: Unlike standard commercial-grade intermediates, ultra-pure 4-Aminoacetophenone specified for API synthesis demands strict monitoring of isomer impurities (specifically 2-aminoacetophenone and 3-aminoacetophenone) down to < 0.10% via high-performance liquid chromatography (HPLC) to prevent non-conforming side reactions in downstream heterocyclic couplings.
| Chemical Property / Parameter | Standard Commercial Grade | High-Purity API / Reagent Grade | Test Method / Analytical Instrument |
|---|---|---|---|
| CAS Number | 99-92-3 | 99-92-3 | CAS Registry Index Verification |
| Molecular Formula / Weight | C8H9NO / 135.16 g/mol | C8H9NO / 135.16 g/mol | Mass Spectrometry (ESI-MS) |
| Appearance | Yellow to Light Brown Powder | Light Yellow Crystalline Powder | Visual Inspection / Colorimetry |
| Purity Assay (HPLC) | ≥ 98.0% | ≥ 99.5% | HPLC-UV (Agilent 1260 / Waters Alliance) |
| Melting Point Range | 103°C – 107°C | 105°C – 107.5°C | Automated Melting Point Apparatus |
| Loss on Drying (Moisture) | ≤ 0.50% | ≤ 0.20% | Karl Fischer Titration (ISO 760) |
| Residue on Ignition (Ash) | ≤ 0.20% | ≤ 0.05% | Gravimetric Ashing (800°C) |
| Single Isomer Impurity | ≤ 0.50% | < 0.10% (2- or 3- isomers) | High-Resolution Reverse Phase HPLC |
Modern fine chemical procurement is no longer restricted to transactional cost-per-kilogram bargaining. Enterprise buyers representing international pharmaceutical giants, specialty chemical producers, and contract research organization (CRO) networks evaluate chemical suppliers through a multi-dimensional risk-mitigation framework. When sourcing 4-Aminoacetophenone at commercial scale, global supply chain directors prioritize three key pillars: continuous batch consistency, regulatory documentation readiness, and structural supply security.
4-Aminoacetophenone is heavily consumed as a precursor for antibacterial sulfonamides, anti-inflammatory compounds, and novel kinase inhibitor derivatives. Any trace contamination of iron catalysts or heavy metals can poison downstream noble metal catalysts (such as Pd/C or Pt/C), causing multi-million dollar batch failures in pharmaceutical reactors.
Global enterprises require complete audit packs prior to plant approval. Leading Chinese manufacturing partners provide comprehensive REACH registration data, US FDA Drug Master File (DMF) support, ISO 9001/14001 certification, safety data sheets (SDS) in 20+ languages, and full elemental impurity analysis matching ICH Q3D guidelines.
Agrochemical and dye manufacturing demand metric-ton bulk volumes with rapid turnaround times. Strategic factory networks maintain flexible multi-ton glass-lined reactor trains (5,000L to 10,000L capacity) alongside continuous crystallization equipment to guarantee uninterrupted spot and contract supply.
China maintains an unprecedented structural edge in the global synthesis of aromatic amines and ketone derivatives. Understanding these macro-economic and technical drivers explains why leading chemical conglomerates partner with qualified Chinese manufacturers.
Chinese production clusters in Hebei, Jiangsu, Shandong, and Zhejiang operate in close physical proximity to basic chemical complexes. Upstream precursors such as benzene, acetic anhydride, nitric acid, and nitrobenzene are sourced domestically with negligible transport premiums. This complete backward integration insulates 4-Aminoacetophenone production from global commodity price spikes.
Historical iron-powder reduction methods created significant hazardous solid waste (iron sludge). Modern Chinese factories have transitioned entirely to eco-friendly continuous catalytic hydrogenation using precious metal catalyst technology in high-pressure reactors. This transition yields higher purity (≥99.5%) while adhering strictly to China's dual-carbon environmental regulations.
Factories operating within state-level chemical parks possess centralized waste-water treatment plants, steam grids, and hazardous chemical shipping terminals. This infrastructure guarantees continuous production during seasonal environmental audits that frequently cause shutdowns in unorganized chemical zones elsewhere in the world.
The chemical versatility of 4-Aminoacetophenone stems from its dual reactive centers: the nucleophilic primary aromatic amine group (-NH2) and the electrophilic carbonyl group (-COCH3). Below are the primary industrial applications across global markets:
Serves as a pivotal precursor for antimicrobial agents, local anesthetics, and cardiovascular drugs. The acetyl moiety undergoes Willgerodt-Kindler reactions or condensation with aldehydes to yield extended conjugated heterocyclic systems used in modern oncology research.
Undergoes rapid diazotization with nitrous acid at 0–5°C to form stable diazonium salts. These intermediate diazonium compounds are coupled with naphthols or aromatic amines to synthesize azo dyes, disperse colorants, and specialized fluorescent markers for textiles and plastics.
In analytical biochemistry and environmental testing labs, 4-Aminoacetophenone is widely applied in colorimetric determination of trace organophosphates, sulfonamide drug residue quantification, and specific enzyme activity assays due to its characteristic UV-Vis absorbance shifts upon derivatization.
Transporting fine chemical powders across international borders requires specialized compliance protocols. Chemical degradation, moisture absorption, and static ignition risks during ocean freight must be engineered out of the logistics loop.
4-Aminoacetophenone is sensitive to prolonged light exposure and ambient air moisture. Industrial export packaging protocols utilize:
While 4-Aminoacetophenone is generally classified as non-regulated or low-hazard under standard GHS transport codes, importing regions (such as the EU, North America, and Japan) enforce strict REACH, TSCA, and ENCS customs checks. Partner factories offer:
To eliminate lead-time bottlenecks, leading Chinese exporters partner with regional distribution centers across Europe (Rotterdam, Antwerp) and North America (Long Beach, Houston). Localized inventory buffers enable 48-hour delivery for urgent laboratory and commercial pilot plant trials.
The global market for aromatic amine intermediates is experiencing a transformation driven by sustainability mandates and continuous processing technologies. Buyers looking to secure long-term manufacturing agreements must align with factories investing in the following technical innovations:
Pioneering manufacturers are transitioning from batch stirred-tank reactors (STR) to continuous flow micro-reactor networks. Micro-fluidic nitration and hydrogenation dramatically improve heat transfer control, eliminate hotspot formation, and restrict impurity generation, guaranteeing batch-to-batch chromatographic reproducibility.
Driven by Scope 3 carbon emission compliance in global pharmaceutical supply chains, Chinese plants are adopting bio-catalysts and recycled noble metal catalyst beds (such as modified Raney-Nickel and recovery-loop Palladium) to lower the carbon footprint per metric ton of product.
Modern quality assurance systems integrate QR-coded Certificates of Analysis directly linked to raw HPLC instrument log files. Procurement teams can instantly verify batch purity, retention time, and operator timestamps prior to breaking drum seals at destination ports.
Address key technical, logistical, and commercial inquiries when procuring 4-Aminoacetophenone from China manufacturers.
We utilize Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) equipped with a C18 stationary phase (e.g., Zorbax SB-C18, 4.6mm x 250mm, 5μm) and a UV-Vis detector set at 305 nm. The mobile phase consists of an isocratic or gradient mix of acetonitrile and phosphate buffer (pH 3.0), allowing clear baseline separation of 2-aminoacetophenone and 3-aminoacetophenone with retention time differences exceeding 2.0 minutes.
4-Aminoacetophenone is prone to slow atmospheric photo-oxidation, which can turn pale yellow crystals into dark amber hues over extended periods. It should be stored in tightly sealed, light-resistant containers under cool (below 25°C), dry, and well-ventilated warehouse conditions away from strong oxidizing agents and direct sunlight. Under these optimized conditions, re-test shelf life is 24 months.
Yes. Beyond standard crystalline powder, our manufacturing partner facilities can provide air-jet micronization to achieve specific D50 and D90 particle size distributions (e.g., D90 < 20 microns) for direct compression formulations or rapid dissolution in pharmaceutical reactors.
Every shipment is dispatched with a comprehensive document package including: Batch Certificate of Analysis (COA), HPLC Chromatogram, Mass Spectrometry (MS) Report, FTIR Spectrum, GHS-compliant Safety Data Sheet (SDS), Packing List, Commercial Invoice, and Certificate of Origin (COO).
For standard inventory material (≥99.5% HPLC purity), dispatch to Chinese main ports (Shanghai, Qingdao, Tianjin) takes 3 to 5 business days. Custom synthesis or specific micronization orders generally require a production cycle of 14 to 21 business days.
Absolutely. We support independent pre-shipment sampling and testing by globally recognized testing agencies such as SGS, Intertek, or Bureau Veritas directly at factory dispatch warehouses.
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