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4-Methylpropiophenone (also termed p-Methylpropiophenone or 1-(4-methylphenyl)propan-1-one) is an organic aromatic ketone acting as an indispensable building block in the high-purity synthesis of fine chemicals, active pharmaceutical ingredients (APIs), photosensitizers, and custom liquid crystals. Below is our factory lot standard analytical baseline.
Certified factory measurements derived via GC-MS, Karl Fischer Titration, and Refractive Index testing:
| Chemical Formula | C10H12O |
| Molecular Weight | 148.20 g/mol |
| CAS Registry Number | 5337-93-9 |
| Appearance | Clear, colorless to pale straw liquid |
| Boiling Point | 238 - 239 °C at 760 mmHg |
| Density / Refraction | 0.993 g/cm³ / n20/D 1.528 |
Every commercial drum adheres strictly to release thresholds confirmed by gas chromatography analysis:
| GC Purity Assay | ≥ 99.5% (Area Normalization) |
| Moisture (Karl Fischer) | ≤ 0.10% (w/w) |
| Toluene / Solvent Residue | ≤ 0.05% (Controlled Volatiles) |
| Total Heavy Metals | ≤ 10 ppm (ICP-MS Tested) |
| Acid Value (mg KOH/g) | ≤ 0.5 Max |
| Single Impurity | ≤ 0.2% |
Analyzing where 4-Methylpropiophenone impacts commercial supply chains across specialty plastics, precision APIs, and agricultural technology.
Serves as a fundamental synthon for central nervous system (CNS) agents, analgesics, and specialized pharmaceutical active ingredients. In contract pharma labs, reproducible enantiomeric purity depends entirely on the low impurity ceiling of the primary ketone building block.
Employed widely as a specialized component in photoinitiator formulation suites for advanced UV coatings, 3D additive manufacturing resins, and screen printing inks where clear non-yellowing characteristics and exact cure kinetic speeds are strict operational demands.
Thanks to its unique, subtly sweet balsamic-fruity aromatic profile, derivatives of CAS 5337-93-9 are synthesized into niche aromatics and organic protective fungicides. Its predictable reactivity profile permits clean acylation, alkylation, and halogenation sequences.
Industrial production of 4-Methylpropiophenone historically relied on batch Friedel-Crafts acylation of toluene with propionyl chloride in the presence of anhydrous aluminum chloride (AlCl3). As global environmental audits intensify, our plant processes have integrated micro-channel continuous flow solutions to elevate yield and lower carbon emission indexes.
By transferring the exothermic acylation sequence into Corning microchannel reactor skids, heat transfer kinetics are controlled down to millisecond windows. This totally suppresses the generation of the ortho-isomer byproduct (2-methylpropiophenone), driving raw selectivity to >99% prior to vacuum fractional column distillation.
Replacing stoichiometric AlCl3 systems with recyclable solid acid zeolites and ionic liquid matrices eliminates hazardous aluminum sludge discharge. Continuous wiped-film evaporators enable 95% closed-loop recovery of volatile organic solvents, drastically lowering life-cycle greenhouse impacts.
International trade of organic ketones requires impeccable end-to-end transparency, robust customs declarations, and strictly audited anti-diversion protocols to avoid border bottlenecks and secure predictable lead times.
Every contract client is subjected to strict Know Your Customer (KYC) documentation, ensuring CAS 5337-93-9 is allocated exclusively for legal industrial, academic, or manufacturing research applications.
Dispatched in fluorinated high-density polyethylene (HDPE) carboys (25 kg), electrostatically grounded PVDF-lined steel drums (200 kg), or 1000L ISO-tanks blankets with ultra-pure dry nitrogen to prevent oxidative degradation.
Seamless sea (FCL/LCL), air cargo, and land transport coordinated via bonded logistics corridors. Full shipping manifest datasets, REACH dossiers, TDS, and safety data sheets (SDS) accompany all dispatches.
Review technical, regulatory, and shipping resolutions regarding 4-Methylpropiophenone sourcing.
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