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5-Bromo-1-pentene serves as a critical terminal alkene and functional organobromine synthon used widely in olefin cross-metathesis, macrocyclic peptide hydrocarbon stapling, and active pharmaceutical ingredient (API) coupling cascades.
| Analytical Parameter | Certified Standard Specification | Typical Factory Lot Performance | Testing Methodology |
|---|---|---|---|
| Chemical Name | 5-Bromo-1-pentene (5-Bromopent-1-ene) | Conforms to Molecular Structure | 1H-NMR, 13C-NMR Identity Match |
| CAS Registry Number | 1119-51-3 | 1119-51-3 Checked | CAS Substance Registry Validation |
| Molecular Formula & Weight | C5H9Br | 149.03 g/mol | Exact Mass: 147.99 g/mol | High-Resolution Mass Spectrometry (HRMS) |
| Assay Purity (GC-FID) | ≥98.0% min (Standard) / ≥99.0% (Pharma Grade) | 98.85% – 99.40% | Capillary GC Separation (Agilent 8890) |
| Physical Appearance | Colorless to pale straw transparent liquid | Clear liquid without suspended sediment | Visual Inspection under 1000 Lux illumination |
| Boiling Point & Density | 126.0 – 129.0 °C @ 760 mmHg | 1.258 g/mL (25°C) | 127.4 °C | 1.256 g/mL | ASTM D1078 / Pycnometry Standard |
| Refractive Index (nD20) | 1.4620 – 1.4660 | 1.4638 | Abbe Refractometer (Sodium D line, 589 nm) |
| Residual Moisture (Karl Fischer) | ≤ 0.05% w/w (Pharma-synthesis dry) | 0.018% w/w | Coulometric Karl Fischer Titration |
| Stabilization / Inhibitor | Optional BHT or Copper turning added upon request | Non-inhibited standard or customer-specified | Spectrophotometric quantitation |
Procurement Quality Note for Synthetic Chemists: When employing CAS 1119-51-3 (5-Bromo-1-pentene) in Grignard activations, organozinc Barbier-type additions, or Ring-Closing Metathesis (RCM), trace protic contaminants and free bromides directly poison sensitive ruthenium-based Grubbs catalysts or deactivate organometallic reagents. Miaoou's manufacturing process enforces an inert atmosphere vacuum distillation followed by dry molecular sieve finishing to maintain ultra-low moisture below 200 ppm.
China’s fine chemical synthesis infrastructure provides unyielding raw material integration, unmatched upstream bromine resource access, and dedicated continuous-flow processing facilities that guarantee price stability and uncompromised bulk output.
Our chemical park plant features direct upstream access to primary bromine reservoirs and basic 1,5-dibromopentane or 4-penten-1-ol feedstocks. By avoiding merchant-market halogen volatility, we insulate international buyers from speculative spot-market price spikes.
Rather than relying on legacy hazardous batch brominations prone to poly-brominated by-products and runaway exothermic profiles, our workshops implement automated micro-reaction continuous bromination. This guarantees batch-to-batch selectivity exceeding 99.2%.
From research test kits (100g – 5kg glass bottles) to metric ton ISO tank distribution, our manufacturing facility supports fast pilot-to-commercial translation. Multi-ton purchase commitments benefit from fixed annual hedging contracts and dedicated inventory reserve vaults.
International fine chemical procurement involves navigating intricate hazardous material classifications, customs codes, and territorial environmental mandates. Miaoou eliminates port-of-entry delays via proactive technical and legal documentation.
Complete regulatory support dossiers are available. For European purchasers, low-tonnage REACH exemptions, Only Representative (OR) coordination, and SDS compliant with Regulation (EC) No 1907/2006 (CLP) are provided standard.
Classified under UN 1993 (Flammable Liquid, N.O.S., Class 3, PG III), 5-Bromo-1-pentene requires UN-certified packaging. We provide certified fluorinated HDPE drums, steel barrels, and shockproof secondary containment complying with IATA, IMDG, and ADR.
We provide Delivered Duty Paid (DDP) multimodal logistics into North America, the European Union, the United Kingdom, Japan, and Southeast Asia, absorbing customs paperwork, tariff classification (HS Code 2903.59), and terminal port inspections.
Every batch ships with dual-signed Certificates of Analysis (COA), accompanying GC-FID spectra, and Karl Fischer titration records. Representative reference lot samples are archived in climate-controlled storage for 24 months to ensure audit traceability.
With its terminal olefin moiety and reactive primary alkyl bromide terminus, CAS 1119-51-3 acts as a bifunctional molecular bridge across modern peptide medicinal chemistry, heterocyclic synthesis, and high-performance functional polymer design.
In contemporary peptide drug design, hydrocarbon stapling dramatically improves therapeutic stability and alpha-helical cell permeability. 5-Bromo-1-pentene is the premier alkylating synthon for generating non-natural olefinic amino acid building blocks (e.g., (S)-2-(4-pentenyl)alanine derivatives) utilized in subsequent ruthenium-catalyzed ring-closing metathesis (RCM).
The primary bromide cleanly undergoes magnesium insertion to generate 4-pentenylmagnesium bromide or reacts in lithium-halogen exchange cascades. This enables smooth introduction of the 4-pentenyl hydrocarbon tail into complex active pharmaceutical intermediates, targeting neurological receptors, antiviral proteases, and metabolic hormone modulators.
Specialty material formulators utilize 5-bromo-1-pentene to functionalize siloxane backbones, crosslink ion-exchange membranes, and introduce reactive allyl/alkene dangling branches onto fluoropolymers. Its pure boiling point profile ensures complete solvent clearance in downstream clean-room cures.
Enterprise buyers are transitioning from fragmented chemical brokers to certified, ESG-audited factory manufacturers capable of delivering rigorous batch integrity and lower environmental impact.
As GLP-1 analogues, amylin mimetics, and oncology peptides expand commercially, pharmaceutical R&D requires multi-kilogram lots of high-purity terminal alkene intermediates. Supply stability in CAS 1119-51-3 has transitioned from an academic reagent concern to a mission-critical commercial supply chain priority.
Global pharmacopoeias (USP, Ph. Eur.) mandate sub-ppm limits for elemental impurities (ICH Q3D). Miaoou’s dedicated production lines utilize all-glass-lined and Hastelloy equipment, avoiding transition-metal leaching (palladium, nickel, lead) that could contaminate late-stage peptide synthesis.
Industrial environmental compliance in China now penalizes inefficient bromine discharge. Our facility operates internal hydrobromic acid oxidation and closed-loop scrubbers, recovering over 96% of halogen by-products. This green chemistry balance protects clients against unexpected regional plant closures.
Get immediate technical clarity regarding MOQ, chemical stabilization, shipping conditions, and custom packaging standards for 5-Bromo-1-pentene.
We supply 5-Bromo-1-pentene at standard commercial purity of ≥98.0% and a specialized pharmaceutical synthesis grade reaching ≥99.0% by GC-FID. Specific impurity profiles detailing residual 1,5-dibromopentane or 4-penten-1-ol can be capped below 0.2% upon contract agreement.
5-Bromo-1-pentene can undergo slow allylic rearrangement or radical-mediated darkening if exposed to heat and UV light over extended periods. We recommend storage at 2–8°C in amber, nitrogen-purged containers. Stabilizers such as 100–500 ppm BHT or copper wire can be added upon request or excluded for sensitive organometallic applications.
Standard packaging configurations include 500g and 1kg amber glass bottles with PTFE seals for lab trials, 25kg UN-approved fluorinated HDPE jerrycans for pilot scales, and 200kg epoxy-lined steel drums for commercial production. Custom nitrogen-purged packaging is standard on all volumes.
Yes. We regularly accommodate international distributors requiring neutral, blind drop-shipping with customer-branded labeling. In addition, prospective buyers can request third-party analytical cross-verification (SGS, Intertek, or Eurofins) before final batch release and vessel lading.
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