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View ProductA comprehensive examination of 4'-Methylpropiophenone (CAS 50390-83-9) across pharmaceutical supply chains, industrial synthesis platforms, and international trade governance.
1-(4-Methylphenyl) propan-1-one represents a core alkyl-aromatic building block. With the expansion of advanced fine-chemical synthesis across the Asia-Pacific region, North America, and the European Union, demand is driven by modern continuous flow production protocols, where intermediate high purity directly dictates downstream API reaction yields.
In adherence to strict global standards—such as EU REACH, TSCA inventory requirements, and regional chemical safety guidelines—our manufacturing sites implement strict End-User Declarations (EUD). Every consignment is documented with comprehensive COAs, SDS, and batch-level HPLC/GC testing to guarantee total trade legitimacy.
China operates as the primary global anchor for aromatic ketonization. Leveraging our integrated upstream toluene and propionyl chloride channels, we insulate international buyers from raw-material price volatility, providing uninterrupted supply for multi-ton industrial contracts.
Quality Assurance Benchmark: Every export batch undergoes quantitative evaluation using dual capillary GC columns (FID) and NMR structure conformation to satisfy USP/EP monograph auxiliary baseline protocols.
| Analytical Parameter | Laboratory Specification | Typical Analytical Value | Methodology |
|---|---|---|---|
| IUPAC Name | 1-(4-Methylphenyl)propan-1-one | Conforms to Structure | 1H / 13C NMR |
| CAS Number | 50390-83-9 | Verified | Registry Match |
| Assay Purity (GC) | ≥ 99.50% | 99.78% | GC-FID Area Normalization |
| Physical Appearance | Clear, colorless to pale straw liquid | Pass | Visual / Photometric Inspection |
| Boiling Point | 238.0 – 240.0 °C @ 760 mmHg | 238.6 °C | Standard Distillation |
| Density (20/4 °C) | 0.988 ± 0.005 g/cm³ | 0.989 g/cm³ | Oscillating U-Tube Pycnometry |
| Water Content (Karl Fischer) | ≤ 0.08% | 0.032% | Coulometric Titration |
Unlocking critical synthetic efficiency across specialized pharmaceutical syntheses, advanced polymer science, and specialty agrochemical manufacturing.
Operates as a high-value aromatic synthon in stereoselective alpha-halogenation and reductive amination cascades. Its rigid aromatic core provides reliable regioselectivity during the synthesis of therapeutic CNS agents, antihypertensive agents, and peripheral vascular compounds.
In modern coating formulations, 1-(4-methylphenyl)propan-1-one derivatives serve as specialized Norrish Type I/II photoinitiators. They generate stable free radicals upon UV excitation, accelerating photopolymerization in graphic arts, optical stereolithography (SLA), and solder resist inks.
The 4-methyl substituted phenone skeleton acts as a targeted structural motif for modern systemic fungicides, acaricides, and plant-growth regulators. Our low-moisture product safeguards catalytic yields during sensitive cyclization steps.
Transitioning beyond legacy Friedel-Crafts protocols to continuous micro-reactor flows and green catalytic frameworks.
Deploying silicon carbide (SiC) microchannel reactors to achieve precise residence time control (<3.5 seconds), eliminating localized thermal hotspots and cutting byproduct generation by 75%.
Replacing standard stoichiometric AlCl3 with regenerative solid superacid and zeolite frameworks (HZSM-5), delivering an atom-economical route with neutral wash water effluents.
Integrating online inline PAT (Process Analytical Technology) driven by AI spectral interpretation, automating live valve-trim adjustments for persistent >99.6% purity.
Engineering downstream recovery pathways that convert spent off-gases and organic mother liquors into recoverable industrial-grade propionic acid and chlorobenzene by-products.
End-to-end commercial solutions tailored for chemical brokers, contract manufacturing organizations (CMOs), and industrial procurement desks.
Available in 200L fluorinated HDPE drums, internally coated epoxy steel containers, and 1000L ISO Tank bulk containers with dedicated dry nitrogen blanketing to halt oxidation during ocean transport.
Direct bonded transshipment channels via Qingdao, Shanghai, and Tianjin ports. Complete DDP/CIF handling with pre-cleared customs documentation, HS classification, and DGM certification for dangerous and non-dangerous categories.
Every commercial delivery includes an analytical dossier: baseline GC chromatograms, residual solvent profiling (ICH Q3C), heavy metals via ICP-MS, and verified stability studies under varying climatic zones.
Addressing quality controls, minimum shipment thresholds, analytical documentation, and customs compliance.
Our standard production yield delivers ≥99.5% pure 1-(4-methylphenyl)propan-1-one determined by Gas Chromatography (GC-FID). For specialized laboratory or pharmaceutical research grades, purities up to 99.8% can be produced via double fractional distillation under vacuum.
Shipments include a Certificate of Analysis (COA) specifying real batch test metrics, an updated 16-section Safety Data Sheet (SDS) conforming to GHS Rev 8, formal packing lists, Commercial Invoices, and signed End-User Declarations (EUD) alongside customs clearance paperwork.
Material is packaged under a dry nitrogen blanket (>99.99% N2) within air-tight, fluorinated HDPE or phenolic-lined steel drums. This safeguards the compound against atmospheric moisture intake and ambient oxidative darkening, ensuring stability across 24-month cycles.
Our standard commercial trial MOQ starts at 25 kg for formulation verification. Bulk commercial agreements are routinely fulfilled in 200 kg drum lots or full 20-foot FCL/ISO-Tank configurations (up to 20 metric tons per container).
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