Procurement teams evaluate these high-yield compounds for stringent pharmaceutical research, API formulation, and batch manufacturing compliance.
An authoritative technical evaluation of 4,4'-(1H-1,2,4-triazol-1-ylmethylene)dibenzonitrile, the cornerstone precursor for non-steroidal third-generation aromatase inhibitors.
| Analytical Parameter | Enterprise Specification Benchmark | USP / Ph. Eur. Method Reference | Release Status |
|---|---|---|---|
| Chemical Nomenclature | 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile | IUPAC / Systematic Standard | Certified |
| CAS Registry Number | 119276-01-6 | Chemical Abstracts Service | Validated |
| Molecular Formula & Weight | C17H11N5 · 285.31 g/mol | High-Resolution MS Identity | Exact Match |
| Physical State & Appearance | White to off-white crystalline solid, odorless | Visual & Optical Microscopy | Conforms |
| Melting Range | 181.0 °C – 184.5 °C | Capillary Melting / DSC Thermal Method | Within Spec |
| Chromatographic Purity (HPLC) | ≥ 99.5% (Isocratic & Gradient Verified) | Ph. Eur. 2.2.29 / Reverse-Phase C18 | Premium Grade |
| Heavy Metal & Elemental Impurities | Lead (Pb) ≤ 2ppm, Arsenic (As) ≤ 1ppm, Total ≤ 10ppm | ICP-MS (USP <232> / <233>) | Ultra-Low |
| Residual Solvents Profile | Methanol < 3000ppm, Toluene < 890ppm, DCM < 600ppm | Headspace Gas Chromatography (GC-FID) | Compliant |
Macro-industry dynamics dictate that pharmaceutical formulators, CDMOs, and generic medicine manufacturers eliminate supply vulnerabilities via direct synthesis partnerships.
Global oncological pipelines cannot tolerate regulatory suspensions or batch recalls caused by unstable precursors. We control starting materials — 4-bromomethylbenzonitrile and 1,2,4-triazole — guaranteeing uninterrupted upstream supply independent of external third-party market fluctuations.
Alkylating and triazole-based process intermediates pose genotoxic risks under ICH M7 guidelines. Our industrial-scale crystallization protocols systematically purge trace halogenated precursors down to sub-threshold concentrations, eliminating costly regulatory holds for drug substance filers.
Every commercial order is backed by full analytical dossiers including 1H-NMR, 13C-NMR, FT-IR, HPLC chromatograms, GC residual solvent analysis, and structural confirmation. We provide Certificate of Origin, SDS (OSHA/CLP compliant), and formal DMF Type II support documentation.
A multi-stage chemical engineering sequence engineered in Shijiazhuang, Hebei, delivering maximum selectivity, optimized reaction kinetics, and minimum carbon impact.
Rigorous quality screening of bis(4-cyanophenyl)methanol derivatives or 4-(bromomethyl)benzonitrile with precise stoichiometric baseline validation.
Regioselective nucleophilic substitution incorporating 1,2,4-triazole under mild alkaline conditions, suppressing unwanted regioisomeric side-products.
Liquid-liquid extraction followed by organic phase washing to remove inorganic salts and trace unreacted starting reagents under vacuum control.
Multistage solvent crystallization using pharmaceutical-grade alcohols to lock in precise polymorph stability and eradicate residual colorants.
Low-temperature rotary conical drying, inert nitrogen purging, sealed anti-static foil containment, and QA release against strict COA benchmarks.
Continuous process improvement, Process Analytical Technology (PAT), and green chemistry paradigms ensure global competitiveness and zero supply disruptions.
Transitioning from conventional batch reactors to modular continuous flow micro-reaction systems. This transition drastically reduces residence time, eliminates localized hotspots, and ensures that critical parameters (temperature, pH, pressure) remain within ±0.1% tolerances throughout multi-ton campaigns.
Employing machine learning models trained on nucleation kinetics and crystal growth data to predict polymorphism under variable cooling gradients. This guarantees precise particle size distribution (D50, D90) tailored for direct downstream tablet compression without secondary micronization.
Implementing membrane vapor permeation and automated distillation columns achieving >95% solvent recovery. By decoupling raw chemical inputs from volatile petrochemical pricing, Hebei Miaoou delivers fixed-price supply stability across multi-year procurement contracts.
End-to-end cold-chain and standard chemical logistics engineered for compliant importation across North America, Europe, LATAM, and Asia-Pacific.
Comprehensive technical and commercial clarity regarding CAS 119276-01-6 synthesis, testing benchmarks, and cross-border delivery.
CAS 119276-01-6 is chemically known as 4,4'-(1H-1,2,4-triazol-1-ylmethylene)dibenzonitrile. It represents the central active molecular core and principal synthetic precursor for Letrozole, an established third-generation aromatase inhibitor extensively manufactured for hormone receptor-positive oncology treatments and reproductive endocrinology research.
During the alkylation coupling stage, the formation of the unwanted 4H-[1,2,4]-triazol-4-yl isomer is suppressed via proprietary low-temperature kinetic control combined with polar aprotic solvent optimization. Any residual isomer is selectively partitioned out in the recrystallization mother liquor, guaranteeing final levels below 0.05% by HPLC.
Every shipment is released with a comprehensive, batch-specific Certificate of Analysis (COA). Standard dossiers include HPLC chromatograms (with relative retention times and peak areas), 1H-NMR spectrum, LC-MS molecular weight confirmation, Karl Fischer water titration, residual solvent GC data, and heavy metal ICP-MS scan.
Yes. In addition to our standard crystalline powder format, we operate clean-room jet milling systems capable of producing tailored micronized grades (e.g., D90 < 20μm or D50 between 5–10μm) tailored specifically to your direct tablet compression or wet granulation operational parameters.
We support trial quantities for R&D pilot validation starting at 100g and 1kg in vacuum-sealed double polyethylene aluminum foil pouches. For commercial industrial manufacturing, standard packaging is 25kg UN-rated tamper-evident fiber drums with multi-layer nitrogen-flushed barrier liners.
Hebei Miaoou Technology maintains established export routes servicing the US, UK, European Union, India, Brazil, and Southeast Asia. We offer flexible Incoterms including EXW, FOB, CIF, and full Delivered Duty Paid (DDP) where our logistics desk executes customs clearance, duty settlement, and door-to-door delivery.
Explore our broader line of research compounds, metabolic modulators, and hormone analogues synthesized under stringent cleanroom parameters.
