Procurement teams source research-grade active compounds manufactured under strict synthesis control. Explore verified catalog items with analytical verification prior to custom Flubromazepam batch inquiries.
Flubromazepam (systematically identified as 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) constitutes a classic halogenated second-generation 1,4-benzodiazepine derivative. Originating chemically in early pharmacological literature during the 1960s, this chemical structure exhibits exceptional chemical stability, marked lipophilicity, and a distinctive halogen substitution footprint featuring both bromine at position 7 and fluorine at the ortho-position of the pendant 5-phenyl ring. In modern chemical research and academic analytical facilities, Flubromazepam serves as a critical certified analytical reference standard (CRM), a biomarker substrate for drug-metabolism pharmacokinetic (DMPK) profiling, and an instrumental calibrant in high-throughput forensic toxicology libraries.
Procuring reference-grade Flubromazepam mandates stringent chemical synthesis oversight. Minor variations in precursor condensation, incomplete cyclization, or sub-optimal bromination lead to recalcitrant isomeric contaminants and dehalogenated degradation analogs that standard flash chromatography fails to isolate. As an established fine chemical and active intermediate manufacturer based in Shijiazhuang, Hebei, China, Hebei Miaoou Technology Co., Ltd. (operating since 2010) integrates continuous crystallization, automated high-pressure preparative chromatography, and exhaustive spectroscopic verification to deliver certified pure materials meeting the rigorous thresholds of forensic laboratories, pharmaceutical screening hubs, and global industrial distributors.
Flubromazepam supplied by our production facilities is synthesized strictly for in vitro pharmacological characterization, receptor binding assays, reference standard chromatogram alignment, and specialized chemical research. Material is packaged with traceable batch COA documentation matching exact LC-MS and Proton NMR datasets for legal import and institutional laboratory verification.
| Analytical Parameter | Certified Standard Specification | Method / Instrument | Commercial Verification |
|---|---|---|---|
| IUPAC Nomenclature | 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one | Chemical Structure Validation | Full structural concordance |
| CAS Registry Number | 2647-50-9 / 618-07-5 (Core Base) | CAS Registry Cross-Check | Verified ChemID Plus standard |
| Molecular Formula & MW | C15H10BrFN2O | 333.16 g/mol | HRMS (High-Resolution MS) | Exact Monoisotopic Mass: 331.9961 |
| Chromatographic Purity | ≥ 99.20% Area Normalization | RP-HPLC at 220nm & 254nm Dual Channel | Single impurity < 0.10% |
| Physical State & Appearance | Off-white to pale crystalline powder | Visual / Microscopic Inspection | Homogeneous crystalline matrix |
| Residual Solvents | Ethanol < 500 ppm, Methanol < 300 ppm, Hexane < 50 ppm | Headspace GC-MS (ICH Q3C compliant) | Zero Class 1 Solvents present |
| Loss on Drying / Moisture | ≤ 0.50% Total Water Content | Karl Fischer Titration (KF) | Ultra-dry nitrogen sealed vials |
Hebei Province stands as a global hub for chemical synthesis and API intermediate production. Our specialized manufacturing infrastructure offers four clear structural advantages over secondary resellers.
We synthesize critical benzophenone precursors—specifically 2-amino-5-bromobenzoyl fluoride derivatives—directly on-site. By eliminating intermediate broker markups, we secure unmatched chemical reproducibility, preventing halogen migration and unreacted starting-material contamination.
Transitioning from traditional stirred batch reactors to automated micro-channel continuous flow systems enables exact thermal regulation during electrophilic halogenation steps. This tight reaction window eliminates thermal hot spots, suppressing toxic poly-brominated side fractions.
Following ring closure, our facility employs industrial-scale DAC (Dynamic Axial Compression) columns loaded with high-efficiency spherical C18 silica. This setup ensures that every single batch, whether 100 grams or 25 kilograms, achieves homogeneous crystallographic purity.
We maintain on-premise 400 MHz Proton/Carbon-13 Nuclear Magnetic Resonance (NMR) spectrometers, triple-quadrupole LC-MS/MS, and automated Karl Fischer analyzers. Release decisions rely exclusively on empirical analytical spectra rather than theoretical third-party promises.
The analytical standard market is undergoing structural shifts toward tighter regulatory compliance, ultra-trace level detection capabilities, and integrated supply validation.
Modern forensic and toxicology screening facilities are moving rapidly away from unit-resolution quadrupole analyzers toward Orbitrap and Q-TOF mass spectrometry. This transition requires certified suppliers to provide accurate mass defect values down to four decimal places, verifying exact elemental composition and isotopic distribution.
With evolving scheduling updates from the UNODC, European EMCDDA, and US DEA concerning novel psychoactive substances (NPS), international logistics demand clear documentation. Cross-border trade requires transparent export declarations, exact HS classification (Chapter 29 heterocyclic intermediates), and strict vetting of certified end-users.
Enterprise buyers and national testing bodies increasingly reject fragmented sourcing. Instead, they require integrated standard libraries where Flubromazepam reference materials are bundled with related synthetic analogs (such as Clonazolam, Etizolam, and Diclazepam) from a single manufacturer with matching chromatographic run times.
Understanding how laboratories use Flubromazepam helps procurement managers select the proper grade, packaging format, and analytical verification profile.
Forensic pathologists and crime labs utilize high-purity Flubromazepam to construct multi-reaction monitoring (MRM) transition pairs on tandem LC-MS/MS equipment. Due to its long metabolic half-life and complex biotransformation into monohydroxy and glucuronidated metabolites, reference standards must feature trace levels below quantifiable limits (LOQ < 0.1 ng/mL) for accurate baseline calibration.
Academic neuropharmacology laboratories investigate the allosteric modulation of GABAA receptor subtypes (specifically α1, α2, α3, and α5 subunit assemblies). Flubromazepam's high lipophilicity and electronegative ortho-fluorine ring configuration make it an essential control substrate when assessing competitive radioligand displacement against standard Diazepam or Flumazenil assays.
Environmental protection agencies track active pharmaceutical ingredients and novel benzodiazepine residues in urban wastewater treatment facilities. Ultra-pure solid reference standards are essential to calibrate solid-phase extraction (SPE) recoveries, matrix-suppression correction equations, and degradation kinetic models in municipal discharge testing.
Every gram of Flubromazepam leaving our facilities follows a documented chain of custody and chemical verification protocol, satisfying institutional audits worldwide.
Incoming 2-fluorobenzoyl chloride and 4-bromoaniline raw inputs undergo gas chromatography release testing.
Precision bromo-substitution and ring-closure under real-time automated thermostatic monitoring.
Industrial HPLC elution isolates the central target fraction, stripping away secondary baseline impurities.
Proton/C13 NMR and HRMS generate definitive analytical fingerprints included in the batch Certificate of Analysis.
Sealed under dry argon or nitrogen in amber borosilicate glass vials protected by light-shielded foil wraps.
When procurement executives and university supply officers evaluate a chemical manufacturer, they look beyond unit pricing to evaluate operational durability, batch consistency, and legal compliance.
Enterprise buyers must present verified technical documentation during ISO/IEC 17025 laboratory audits. We furnish every shipment with comprehensive Certificates of Analysis (COA), complete raw HPLC chromatograms, NMR resonance peak assignments, mass spectrometer calibration traces, and complete Safety Data Sheets (SDS in GHS format).
Fine chemicals require deliberate customs handling to avoid clearance bottlenecks. Our export department handles precise commercial invoices, declarations under the proper Harmonized System (HS) codes, robust secondary containment to prevent puncture risks, and real-time end-to-end parcel tracking.
Whether an analytical laboratory requires 100 mg lyophilized vials for direct instrument autosamplers or an industrial client requires 10-kilogram bulk pilot drums for synthesis, we offer custom aliquoting, barcode labeling, and moisture-free nitrogen sealing tailored to buyer specifications.
Direct, transparent answers covering physical properties, storage stability, purity certification, and international B2B ordering procedures.
Every delivery includes a batch-matched, fully signed Certificate of Analysis (COA). This document displays the exact chromatographic purity calculated from reverse-phase HPLC at 254 nm, Proton (1H) and Carbon-13 (13C) NMR spectral readouts confirming chemical structure, High-Resolution Mass Spectrometry (HRMS) verifying molecular weight, and Karl Fischer titration measuring residual moisture.
Flubromazepam exhibits strong solubility in organic solvents: practically soluble in Dimethyl Sulfoxide (DMSO) up to ~30 mg/mL, in anhydrous Dimethylformamide (DMF) up to ~25 mg/mL, and in absolute Ethanol up to ~15 mg/mL with gentle ultrasonication. It is practically insoluble in aqueous buffers (<0.05 mg/mL at pH 7.2). For analytical standard preparation, we advise creating stock solutions in HPLC-grade acetonitrile or methanol, storing them at -20°C in amber glass.
As an isolated dry powder, Flubromazepam displays notable chemical stability. It should be preserved in its original hermetically sealed containers at controlled temperatures (-20°C for long-term multi-year storage, or 2°C to 8°C for active quarterly research), shielded from UV radiation, heat sources, and ambient air moisture. Under these conditions, verified stability exceeds 36 months without measurable degradation.
Yes. In addition to high-purity non-labeled Flubromazepam, our synthetic laboratory accepts custom contracts for deuterated internal standards (such as Flubromazepam-d4) utilized as internal references in quantitative LC-MS/MS bioanalytical assays. We also support pilot-scale crystallization with customized particle sizes and specific polymorphic distribution requirements.
As a responsible chemical manufacturer operating since 2010, we require all prospective buyers to supply verified institutional credentials, including corporate or university tax registration, documented intended research use declarations, and verification that the compound aligns with destination jurisdiction legislation. We do not supply materials for unauthorized handling, clinical trials, or consumer formulations.
Standard analytical inventory (gram-scale to standard laboratory packaging) ships within 24 to 48 hours following document verification. Custom multi-kilogram manufacturing, deuterated standard production, or specialized clean-room vial packaging generally requires a 2- to 4-week synthesis and analytical qualification lead time, outlined clearly in the formal proforma quotation.
Explore our broader manufacturing capabilities across solid-phase peptide synthesis, endocrine research hormones, and specialty biological raw materials produced with identical analytical rigor.
