Batch-verified purity, standardized COA documentation, and flexible international logistics.
Phenylacetamide (CAS NO. 103-80-0), also structurally known as 2-Phenylacetamide or Benzeneacetamide, represents an indispensable organic building block within the global chemical supply chain. Positioned at the intersection of active pharmaceutical ingredient (API) synthesis, advanced agrochemical formulation, and fine chemical performance additives, Phenylacetamide's quality integrity directly dictates downstream yield efficiency.
As leading China Phenylacetamide manufacturers, Hebei Miaoou Technology Co., Ltd. combines advanced catalytic hydrolysis pathways with rigorous analytical verification (HPLC, GC-MS, NMR) to deliver research- and commercial-grade Phenylacetamide. By solving key industry bottlenecks—such as trace nitrile impurities and moisture variability—our production lines supply multinational pharmaceutical research centers, Contract Development and Manufacturing Organizations (CDMOs), and industrial chemical procurement agents worldwide.
IUPAC Name: 2-Phenylacetamide
Molecular Formula: C8H9NO
Molecular Weight: 135.16 g/mol
CAS Registry Number: 103-80-0
EINECS Number: 203-145-1
Appearance: Off-white to pure white crystalline powder
Melting Point: 154°C – 157°C (lit.)
Solubility: Soluble in ethanol, hot water, and chloroform; sparingly soluble in ether.
Understanding supply chains, geographic demand shifts, and economic advantages of Chinese manufacturing.
Over 65% of the global supply of Phenylacetamide intermediate derivatives originates from specialized chemical clusters in East Asia, with China maintaining a primary position. The strategic integration of upstream precursor supplies—such as Benzyl Cyanide (Phenylacetonitrile) and toluene derivatives—allows China-based facilities to maintain continuous chemical synthesis cycles unaffected by global raw material shocks.
Hebei Miaoou Technology Co., Ltd. operates state-of-the-art synthesis plants leveraging vertically integrated raw material networks. This enables predictable lead times, reduced margin volatility, and stable large-scale commercial output for overseas buyers across Europe, North America, and Southeast Asia.
The commercial trajectory of Phenylacetamide is closely linked to innovations in central nervous system (CNS) therapeutics, anticonvulsant pharmaceutical formulations, and selective agricultural herbicides. As drug discovery platforms expand their target space, demand for high-purity functionalized acetamides has scaled exponentially.
Furthermore, the growth of green agrochemical intermediates requiring low toxicological footprints has elevated Phenylacetamide from a basic commodity chemical into a high-spec fine chemical intermediate requiring strict impurity profiling.
Transitioning from traditional acid-catalyzed hydration to zero-emission continuous micro-reactor technology.
Historically, commercial manufacturing of Phenylacetamide relied heavily on controlled acid/alkaline hydrolysis of benzyl cyanide (phenylacetonitrile). While cost-effective, classic chemical hydrolysis generates substantial inorganic salt waste streams and risks over-hydrolysis to phenylacetic acid.
To overcome these legacy constraints, our engineering teams have pioneered a dual-route synthesis matrix:
| Quality Parameter | Technical / Industrial Grade | Pharmaceutical Research Grade | Analytical Test Protocol |
|---|---|---|---|
| Assay (Purity) | ≥ 98.5% | ≥ 99.5% | HPLC (Normalized Peak Area) |
| Appearance | Off-white Crystalline Powder | Pure White Micro-Crystals | Visual / Colorimetric Inspection |
| Melting Range | 153.0°C – 156.0°C | 155.0°C – 157.0°C | Capillary Melting Point Apparatus |
| Loss on Drying | ≤ 0.50% | ≤ 0.10% | Vacuum Drying at 105°C |
| Related Substances (Phenylacetic Acid) | ≤ 0.80% | ≤ 0.05% | High-Performance Liquid Chromatography |
| Heavy Metals (Pb, As, Cd) | ≤ 20 ppm | ≤ 5 ppm | ICP-MS Spectral Analysis |
Serving cross-sector industrial ecosystems with tailored chemical processing options.
Phenylacetamide acts as a precursor for anticonvulsants (such as Phenacemide derivatives), analgesic active agents, and hypnotic therapeutics. Its strict control over residual chloride and acid content ensures smooth downstream coupling reactions without catalyst poisoning.
In crop protection chemistry, functionalized phenylacetamide derivatives act as structural moieties for selective fungicides and pre-emergence herbicides. Our custom particle micronization capabilities allow precise dissolution profiles in emulsifiable concentrate (EC) formulations.
Phenylacetamide derivatives serve as thermal stabilizers, plasticizers, and cross-linking organic intermediates in polyamide formulation and specialized dye synthesis. Controlled batch consistency prevents color degradation in finished industrial polymers.
Hebei Miaoou Technology Co., Ltd. integrates quality controls across the entire manufacturing lifecycle. Each batch undergoes multi-stage verification before dispatch:
Every consignment includes a batch Certificate of Analysis (COA) containing HPLC chromatograms, GC residual solvent tests, and Karl Fischer water content results.
Fully compliant with global GHS hazard classification standards. REACH registered documentation, US FDA DMF capabilities, and comprehensive Safety Data Sheets (SDS).
Packaged in humidity-sealed 25kg fiber drums with double PE inner liners, or custom aluminum foil vacuum packaging for high-purity research orders.
Hebei Miaoou Technology Co., Ltd. simplifies international chemical procurement through clear commercial operations:
Addressing key inquiry parameters for procurement teams, synthetic chemists, and supply chain managers.
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