Verified batch-to-batch consistency with accompanying Analytical HPLC, MS data, and export documentation ready for industrial and research workflows.
Known systematically as tert-Butyl 4-oxopiperidine-1-carboxylate (or 1-Boc-4-piperidone), CAS 40064-34-4 represents an indispensable monocyclic building block in cutting-edge pharmaceutical synthesis, medicinal lead discovery, and heterocyclic ligand manufacturing.
| Analytical Parameter | Monograph Compendial Standard | Factory In-House QC Limits (Lot Release) | Testing Methodology |
|---|---|---|---|
| Chemical Name | tert-Butyl 4-oxopiperidine-1-carboxylate | 1-Boc-4-piperidone / N-Boc-4-piperidone | IUPAC Standard Naming |
| CAS Registry Number | 40064-34-4 | Validated Chemical Structure Identity | CAS Registered Database |
| Molecular Formula / Weight | C10H17NO3 | 199.25 g/mol (Monoisotopic: 199.1208) | High-Resolution MS (HRMS) |
| Physical Appearance | White to off-white crystalline solid / powder | Conforms to reference physical standard | Visual / Automated Colorimeter |
| Melting Point Range | 73.0 °C to 77.0 °C | 74.2 °C – 76.5 °C sharp transition | Capillary Melting Method (USP <741>) |
| Assay Purity (Area %) | ≥98.5% | ≥99.0% - 99.8% (Target Release) | HPLC-UV / GC-FID normalization |
| Residual Solvents | Meets ICH Q3C Guidelines | Methanol <500ppm, Ethyl Acetate <800ppm | Headspace Gas Chromatography (GC-HS) |
| Heavy Metals Contamination | <10 ppm total | Pb <2ppm, As <1ppm, Cd <0.5ppm, Hg <0.1ppm | Inductively Coupled Plasma (ICP-MS) |
Every commercial batch produced within our Hebei facility undergoes complete 1H-NMR and 13C-NMR characterization. Singlet resonances for the nine tert-butoxy protons at δ ~1.48 ppm and characteristic piperidone methylene triplets are precisely benchmarked to ensure no ring-opened degradation or deprotection impurities.
The tert-butoxycarbonyl (Boc) carbamate group delivers optimal acid-labile protection while resisting neutral hydrolysis and mild nucleophilic attack. Thermal degradation profiles under non-isothermal TGA show thermal integrity sustained beyond 140 °C, facilitating secure transcontinental shipping under dry, temperate controls.
Secondary amine residues such as piperidin-4-one hydrochloride can catalyze side-chain polycondensation during API functionalization. Our dual-phase solvent extraction and automated recrystallization cascades suppress unreacted secondary amines to <0.05%, preventing pipeline contamination.
Global pharmaceutical sourcing directors choose our direct manufacturing ecosystem not merely on unit cost, but to eliminate multi-tiered distributor markup, eliminate shipment stockouts, and leverage unmatched raw material integration.
Our synthesis network controls key base raw materials—including di-tert-butyl dicarbonate (Boc anhydride) and 4-piperidone salts—directly from regional basic chemical clusters in Northern and Eastern China. By insulating our operational throughput from external merchant market fluctuations, we provide long-term contract pricing stability (12 to 36 months) for enterprise procurement programs, shielding commercial pipelines from volatile speculative chemical traders.
Moving beyond classical batch stirred reactors that suffer from local hot-spot degradation and variable product coloration, our manufacturing sites employ automated micro-channel continuous flow reactors. Continuous acylation and solvent exchange ensure complete reaction kinetics under precise isothermal monitoring. This modern continuous manufacturing infrastructure yields uniform crystals, zero batch stratification, and an immediate scale-up potential exceeding 5,000 kilograms per month.
Located in an officially licensed Provincial Chemical Industrial Park with closed-loop VOC recovery and high-efficiency wastewater treatment plants, our facilities operate under continuous environmental safety oversight, avoiding regulatory shutdown risks common with uncertified workshops.
From 100-gram R&D trial samples to multi-metric-ton bulk containers, we ensure zero process discrepancy. Synthetic routes, crystallization matrices, and filtration parameters remain identical across all volumes, minimizing analytical re-validation costs for our global partners.
We maintain an active, quality-released strategic buffer inventory of 5,000 kg to 10,000 kg of CAS 40064-34-4 at our climate-controlled logistics hubs in Shijiazhuang, Shanghai, and Guangzhou, enabling expedited same-week shipment upon proforma confirmation.
Industrial B2B chemical acquisition requires exhaustive traceability, validated analytical controls, and uncompromising compliance with Good Manufacturing Practice (GMP) intermediate guidance.
Every commercial delivery is backed by a fully traceable batch Certificate of Analysis (COA), high-resolution HPLC chromatograms with UV integration tables, Liquid Chromatography-Mass Spectrometry (LC-MS) data verifying molecular mass, and Infrared (FT-IR) comparative spectrum confirmation.
Downstream pharmaceutical and API synthesis requires exact quantification of Class 2 and Class 3 residual solvents. Our static headspace gas chromatography assays ensure total volatile residuals remain well below international compendial thresholds, ensuring your final formulated product avoids toxicological concerns.
We welcome third-party quality audits (such as SGS, Intertek, or customer QA representatives) and facilitate remote virtual plant inspections. Our Quality Management System (QMS) aligns with ICH Q7 directives for active pharmaceutical ingredients and key intermediates, guaranteeing ironclad data integrity.
Standard industrial packaging utilizes double anti-static food/pharma grade polyethylene bags sealed with tamper-evident serial bands, enclosed inside airtight nitrogen-flushed aluminum foil barrier envelopes, and protected within heavy-duty fiber drums (25 kg net weight) certified for UN hazardous and general transport.
Cross-border chemical procurement demands meticulous documentation, strict alignment with customs tariff classifications, and proactive hazardous/non-hazardous chemical declarations.
We supply 16-section compliant Safety Data Sheets (SDS) formulated in compliance with OSHA GHS (USA), CLP Regulation (EC No 1272/2008), and national chemical regulatory frameworks in over 12 languages. Dedicated regulatory specialists support pre-registration and tonnage declarations for importers throughout Europe, the UK, North America, and APAC.
Misclassification creates customs holds and substantial demurrage penalties. We declare CAS 40064-34-4 under standard Harmonized Tariff Schedule (HTS) Code 2933.39.90.90 (Heterocyclic compounds with nitrogen hetero-atom only, containing an unfused pyridine ring). Proper non-controlled chemical certifications eliminate customs delays.
Whether you require express sample dispatch via air courier (FedEx, DHL), temperature-regulated air cargo, or ocean shipping (FCL/LCL) to Rotterdam, Hamburg, Los Angeles, Singapore, or Busan, our export specialists manage end-to-end bill of lading, customs brokerage, and door-to-door delivery with live tracking.
CAS 40064-34-4 acts as an essential functionalized heterocyclic scaffold across multiple therapeutic classes, from neuropharmacology to oncology.
The electrophilic ketone core at position 4 enables rapid, high-yield molecular diversification:
The global demand for functionalized piperidines is projected to grow at an annual CAGR exceeding 6.8% through 2032, driven by new kinase inhibitors, GLP-1 companion therapeutics, and targeted oncology programs.
Emerging Industry Trends:
Whether your scientific teams operate within early-stage screening incubators or run high-throughput commercial production lines, our CAS 40064-34-4 accommodates exact scale-specific specifications.
For early-phase parallel medicinal chemistry, high assay purity (>99%) and crystal homogeneity are critical to prevent false-positive bioassay hits. We supply researchers with validated 100g, 500g, and 1kg hermetically sealed bottles complete with detailed batch NMR and MS data sets for rapid laboratory screening.
During Phase I and Phase II clinical candidate campaigns, contract development and manufacturing organizations (CDMOs) require batch sizes between 25 kg and 200 kg. Our intermediate consistency guarantees identical crystallization morphology, predictable filtration rates, and zero process adjustments during scale transition.
For approved, commercial pharmaceutical drugs utilizing 4-substituted piperidine cores, reliability of continuous supply is essential. We establish dedicated multi-ton supply agreements accompanied by annual volume rebates, safety reserve stocks, and comprehensive change-control notifications (CCN).
Comprehensive technical and commercial answers designed to streamline due diligence for chemical procurement teams and analytical scientists.
Explore our extended synthetic portfolio manufactured under strict quality surveillance for laboratory analysis, formulation trials, and developmental chemistry.
