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Access Product SpecsA rigorous review of molecular characteristics, purity protocols, enzymatic pathways, and strategic procurement imperatives.
Chemical Definition & Molecular Nomenclature: Registered under Chemical Abstracts Service registry number CAS 9002-61-3, this substance is structurally categorized as Chymotrypsin (specifically Chymotrypsin A, EC 3.4.21.1). As an endopeptidase belonging to the S1 serine endopeptidase family, it plays a vital and irreplaceable role across therapeutic production, biotechnology purification matrices, and precision peptide chain mapping. Secreted naturally by the pancreas as the inactive precursor chymotrypsinogen, industrial synthesis and bioprocess manufacturing leverage precisely controlled enzymatic activation or recombinant fermentation expressions to yield stable, lyophilized enzyme formulations of clinical and industrial caliber.
Catalytic Mechanism & Active Cleavage Specificity: The macromolecular functionality of CAS 9002-61-3 operates through a catalytic triad consisting of His-57, Asp-102, and Ser-195. The primary specificity pocket (S1 subsite) contains a hydrophobic cavity defined by Ser-189, Gly-216, and Gly-226, allowing deep insertion of hydrophobic aromatic side chains. Consequently, CAS 9002-61-3 preferentially hydrolyzes peptide amide bonds at the carboxyl side of aromatic amino acids—principally L-phenylalanine, L-tyrosine, and L-tryptophan—with secondary cleavage activity observed near leucine and methionine residues. Understanding these specific cleavage kinetics is paramount for B2B procurement teams who utilize the compound in downstream bioprocess digestion and analytical structural elucidation.
Optimized process engineering, vertically integrated supply logistics, and advanced multi-column purification technologies.
Modern Chinese manufacturing facilities utilize automated distributed control systems (DCS) for the crystallization, extraction, and activation of CAS 9002-61-3. Continuous operational parameters eliminate human variation, ensuring homogeneous enzyme activity and consistent lot-to-lot kinetics.
Direct supply agreements for bovine pancreas raw material sources combined with large-scale domestic synthesis of chromatographic media protect buyers from supply chain shocks. This geographic vertical integration insulates operations from cross-border shortages and erratic price inflation.
By operating multi-ton production blocks under clean-in-place (CIP) and sterilize-in-place (SIP) sanitary designs, Chinese facilities maintain unit cost efficiencies unattainable in decentralized small-scale labs, allowing competitive wholesale pricing without compromising analytical rigor.
From peptide synthesis validation to clinical formulation excipients, discover the precise operational parameters.
Used extensively as a primary or orthogonal digestion enzyme alongside trypsin to construct high-resolution mass spectrometry fingerprints. Chymotrypsin allows researchers to map post-translational modifications and elucidate hydrophobic domains unreachable by traditional basic amino acid cleavage.
In pharmaceutical formulations, CAS 9002-61-3 is prepared in ointments, sprays, and hydrogels for enzymatic wound debridement. Its proteolytic action cleaves necrotic tissues and fibrinous exudates without damaging healthy, vascularized epithelial boundaries.
Modern green chemistry employs CAS 9002-61-3 in low-water organic solvents to drive kinetically controlled reverse peptide synthesis. This biocatalytic method provides enantiomeric stereospecificity impossible through purely chemical coupling reagents, lowering racemization rates.
Purified USP/EP grades are formulated into micro-dose ophthalmic solutions for enzymatic zonulolysis during intracapsular cataract extractions, breaking delicate ciliary zonules while minimizing risk of mechanical trauma to adjacent intraocular structures.
Engineered as a core component in clinical pathology and blood coagulation test kits. CAS 9002-61-3 standardizes background plasma digestions, ensuring immunoassay precision and eliminating interference caused by circulating endogenous protein complexes.
Employed in high-value nutritional hydrolysate generation, specifically targeting hypoallergenic whey protein digests. The enzyme releases bio-active peptides associated with blood pressure regulation and immunomodulation without imparting bitter terminal peptides.
Market forecasts for 2026–2032 highlight growing regulatory demand for viral inactivation, TSE/BSE certification, and non-animal recombinant alternatives.
Regulatory Compliance and TSE/BSE Documentation: When sourcing CAS 9002-61-3 derived from bovine pancreatic origins, procurement teams in North America, the European Union, and Asia-Pacific must prioritize raw material traceability. Leading manufacturers maintain rigorous dossiers outlining the geographic disease status of animal herds, fully complying with EDQM Certificate of Suitability (CEP) standards or FDA Drug Master Files (DMF). Furthermore, validated viral clearance studies utilizing nanofiltration, heat treatment, and low pH holding cycles are now non-negotiable requirements for industrial release.
The Transition Toward Recombinant Expression: Emerging trends show a steady transition from tissue-extracted enzymes toward recombinant microbial systems (such as Pichia pastoris or Escherichia coli). Recombinant CAS 9002-61-3 eliminates animal-origin risks, guaranteeing complete freedom from adventitious viruses and secondary protease contaminants (such as trypsin contamination). Enterprise buyers are actively updating supply audits to accommodate hybrid procurement models that ensure consistent dual-stream redundancy.
Every shipment is backed by batch-specific COAs, high-performance liquid chromatography (HPLC) profiles, SDS-PAGE purity runs, residual heavy metal analyses, bioburden checks, and valid country-of-origin health certificates.
Enzymatic catalysts require strict thermal stability. Products are vacuum-sealed in nitrogen-flushed pharmaceutical-grade containers and transported with calibrated data loggers ensuring sustained conditions (-20°C or 2-8°C) from warehouse to consignee.
We supply buyers with qualified regulatory support packages, including complete elemental impurity statements (ICH Q3D), residual solvent certificates (ICH Q3C), and on-site audit availability for qualified enterprise contracts.
Eliminating variability across critical enzymatic parameters before batch release and export dispatch.
Strict veterinary and biosafety release criteria. Testing for residual moisture, microbiological bioburden, and heavy metal baseline screening.
Tangential flow filtration (TFF) and selective ion-exchange chromatography to isolate target fractions while depleting trace ribonucleases and endotoxins.
Validation of substrate turnover rates using synthetic chromogenic substrates (e.g., BTEE) under strict spectroscopic temperature control (25°C ± 0.1°C).
Controlled freeze-drying cycles retaining non-denatured tertiary protein architecture, followed by hermetic sealing under dry inert nitrogen gas.
Direct technical answers addressing purity verification, storage stability, bulk supply scalability, and analytical testing standards.
Every commercial batch of CAS 9002-61-3 is assayed according to standardized pharmacopeial monographs (USP, EP, or BP). Specific activity is conventionally quantified utilizing N-benzoyl-L-tyrosine ethyl ester (BTEE) as the primary synthetic substrate at 256 nm, or alternatively with ATEE. The spectrophotometric change in absorbance is calculated against an international reference standard, with results clearly reported in USP Units/mg or Katals/mg on the accompanying COA.
Trypsin co-extraction is an inherent risk in animal pancreas extraction. Our manufacturing facilities employ dedicated affinity chromatography steps and specialized chemical inhibitors (such as TLCK) during precise downstream processing windows to selectively inactivate and remove trace trypsin activity. The final material is verified to contain less than 0.1% or non-detectable levels of secondary protease activity using BAEE spectrophotometric assays.
We support a broad spectrum of procurement needs ranging from laboratory pilot batches (10g, 50g, 100g in sealed amber borosilicate glass vials) up to industrial manufacturing quantities (1kg, 5kg, and 25kg multi-layer pharmaceutical foil bags encased in UN-approved fiber drums). Custom batch sizing, specific filling configurations, and OEM white-label serialization are fully supported under formal supply agreements.
Lyophilized CAS 9002-61-3 should be stored desiccated at -20°C for long-term stability (≥36 months). For reconstitution, the enzyme should be dissolved in cold 1mM HCl or a low pH buffer (pH 2.0 to 3.0) containing 2mM CaCl2, which stabilizes the structure and effectively suppresses autolytic degradation. Working enzyme solutions should be kept on ice and utilized promptly within working shifts, or snap-frozen in single-use aliquots at -80°C.
Shipments are dispatched with an exhaustive export documentation dossier: Commercial Invoice, Packing List, Certificate of Analysis (COA), Safety Data Sheet (SDS) conforming to GHS guidelines, Non-Hazardous Cargo Declaration, TSE/BSE Freedom Statement, and Official Veterinary Health Certificates issued by authorized government entry-exit inspection bureaus (CIQ).
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