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An authoritative evaluation of Boldenone Cypionate (17β-cyclopentylpropionate-androsta-1,4-dien-3-one): stereochemistry, lipophilic esterification kinetics, thermal thresholds, and chromatographic fingerprinting.
CAS 106505-90-2 represents the cyclopentanepropanoic acid ester conjugate of boldenone. The addition of the cypionate ester at the C-17β hydroxyl position dramatically increases molecular lipophilicity (Calculated LogP ~ 4.92), reducing dissolution rates in aqueous physiological fluids and extending the release half-life in intramuscular oily vehicles to approximately 8 to 11 days.
With an empirical molecular formula of C26H38O3 and a molecular mass of 398.58 g/mol, raw CAS 106505-90-2 appears as a pale white or yellowish crystalline solid. Due to the bulky aliphatic nature of the cypionate group, it demonstrates a distinct melting point transition between 104°C and 108°C, distinguishing it spectroscopically from its undecylenate counterpart (CAS 13103-34-9).
The compound exhibits virtually zero solubility in deionized water (<0.01 mg/mL) while showing extensive solubility in organic solvents including ethanol, ethyl oleate, benzyl alcohol, and benzyl benzoate. This makes it an ideal raw candidate for standardized lipid emulsions, standard reference calibrations, and micro-dose kinetic assays.
| Analytical Parameter | Pharmacopeial / Factory Standard | Typical Laboratory HPLC/GC-MS Result | Compliance State |
|---|---|---|---|
| Chemical Name | 17β-(3-Cyclopentylpropanoyloxy)androsta-1,4-dien-3-one | Consistent with structure (1H, 13C-NMR confirmed) | Validated |
| Assay Purity (HPLC) | ≥ 98.50% (Anhydrous Basis) | 99.15% - 99.42% (Area Normalization) | Validated |
| Melting Range | 103.5°C to 108.5°C | 105.2°C – 107.1°C (Capillary DSC) | Validated |
| Loss on Drying (LOD) | ≤ 0.50% w/w | 0.18% - 0.24% (105°C, 3 hours) | Validated |
| Residual Solvents (ICH Q3C) | Methanol < 3000ppm; Ethanol < 5000ppm; Hexane < 290ppm | Below Detection Limits (Headspace GC-FID) | Validated |
| Heavy Metals (ICP-MS) | ≤ 10 ppm (Total: Pb, Cd, As, Hg) | < 2.5 ppm | Validated |
How Chinese industrial clusters in Hebei, Shandong, and Hubei combine large-scale bioconversion, continuous chemical synthesis, and downstream analytical control to outperform global competitors.
The core advantage of Chinese chemical enterprises lies in vertical integration. Starting from natural soy and pine phytosterols, massive biological fermentation facilities synthesize 4-androstenedione (4-AD) and androstadienedione (ADD) at scale. Having direct domestic access to ADD raw precursors eliminates overseas dependency and curtails synthesis costs by up to 35% compared to European or Indian facilities.
Advanced factories utilize automated continuous-flow microreactors to couple 1-dehydrotestosterone with cyclopentylpropionyl chloride. This microchannel methodology minimizes exothermic localized spikes, eliminates thermal degradation, suppresses dimerization impurities, and yields batch purity levels consistently exceeding 99.0% on first-pass crystallization.
Leading Chinese exporters do not simply ship raw chemical powders; every production lot is accompanied by a certified dossier consisting of batch-specific Certificates of Analysis (COA), HPLC chromatograms, Fourier-Transform Infrared (FT-IR) spectra, and Headspace Gas Chromatography profiles for residual solvent verification.
From in vitro mammalian androgen-receptor affinity screening to specialized veterinary anabolic formulations, explore where CAS 106505-90-2 is strategically positioned across world markets.
In veterinary medicine and animal husbandry research, boldenone derivatives serve as model substances for examining nitrogen retention, lean tissue accretion, and bone mineral density enhancement in equine and bovine models. CAS 106505-90-2 serves as a vital analytical standard for quantitative HPLC and LC-MS assay calibration.
Academic institutions and contract research organizations (CROs) deploy ultra-pure Boldenone Cypionate in structural bioassays. Because of its structural delta-1,4-diene framework, it exhibits lower aromatization into estrogens compared to testosterone, acting as a crucial molecular probe for examining non-genomic endocrine signaling cascades.
With international anti-doping bodies (such as WADA) enforcing stringent sub-nanogram threshold limits, forensic laboratories require reliable, highly verified batches of CAS 106505-90-2 and its corresponding metabolites (17β-hydroxyandrosta-1,4-dien-3-one and epimers) to execute mass-spectrometric retention time calibration.
Navigating the cross-border distribution of sensitive biochemical intermediates requires deep logistical redundancy, customized packaging, and proactive customs risk architecture.
For international enterprise buyers across North America, Europe, Southeast Asia, and Latin America, tier-1 Chinese manufacturers provide comprehensive Delivered Duty Paid (DDP) logistics channels. By handling local tax assessments, bonded transit declarations, and partner logistics networks, parcels bypass commercial customs bottlenecks without risk of operational delays.
Because raw ester powders are prone to moisture-induced ester hydrolysis under elevated temperatures, factory shipments implement triple-layer protection: inner food/pharma-grade heat-sealed polyethylene barrier liners, secondary aluminum foil vacuum bags with embedded desiccants, and external puncture-resistant composite fiber drums or cartons.
Procurement teams evaluate suppliers based on batch consistency. Top Chinese facilities commit to independent third-party verification (such as SGS, Eurofins, or accredited domestic analytical labs) and support formal service-level agreements guaranteeing replacement or refund in the unlikely event of HPLC assay divergence.
Clear, authoritative guidance on technical specifications, regulatory distinctions, analytical re-testing, and shipping standards for CAS 106505-90-2.
CAS 106505-90-2 is Boldenone Cypionate (esterified with cyclopentylpropionic acid, molecular formula C26H38O3, solid crystalline state). CAS 13103-34-9 is Boldenone Undecylenate (esterified with undecylenic acid, C30H44O3, typically an oily liquid or low-melting waxy substance at ambient temperature). Both share the same active base core but possess drastically different melting points, molecular weights, and carrier-oil solubility profiles.
Dimer impurities occur during the acidic condensation and esterification steps. Advanced Chinese chemical plants use controlled low-temperature continuous-flow reactors (0°C to 5°C) with dry pyridine or DMAP as acid scavengers, followed by multi-stage recrystallization using a customized methanol/deionized water solvent system, limiting dimer impurities to strictly below 0.15%.
Every export lot includes a signed Certificate of Analysis (COA) indicating exact HPLC assay purity, moisture content (Karl Fischer), melting point curve, heavy metals content via ICP-MS, and residual solvents via Headspace GC. High-resolution HPLC raw chromatograms and MS spectra can be furnished prior to dispatch.
Standard packaging configurations include 100g, 500g, and 1kg heat-sealed aluminum foil vacuum pouches with tamper-evident seals. For industrial clients purchasing at commercial volumes, products are packaged in 10kg, 20kg, and 25kg UN-rated fiber drums containing dual food-grade anti-static inner polyethylene liners.
To prevent ester cleavage or thermo-oxidative degradation, raw powder should be stored in a dry, dark, well-ventilated facility at controlled temperatures between 2°C and 8°C (or controlled ambient below 20°C for short durations). Containers must remain tightly sealed under nitrogen blanket if opened.
We partner with dedicated chemical logistics brokers offering DDP (Delivered Duty Paid) door-to-door transit channels. The carrier manages all import declarations, internal EU/US transfer points, and domestic inland deliveries, ensuring 100% customs release security and zero seizure exposure for verified buyers.
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