Direct supply from Hebei Miaoou Technology Co., Ltd. (Diyingchem): Rigorously synthesized and batch-tested active compounds, peptides, and pharmaceutical intermediates available for immediate shipment.
A rigorous examination of global supply streams, organic synthesis paradigms, and quality expectations shaping international B2B procurement for Dimethocaine intermediates.
CAS 94-15-5, chemically designated as (3-diethylamino-2,2-dimethylpropyl) 4-aminobenzoate and systematically known under synonymous trade and chemical designations as Dimethocaine or Larocaine, represents an ester of 4-aminobenzoic acid (PABA) bearing a branched dialkylaminoalkyl sidechain. Possessing the empirical formula C16H26N2O2 and a molecular mass of 278.39 g/mol (free base form), this molecule serves as a critical structural analog within neurological, bio-organic, and active anesthetic mechanism investigations.
Within current global fine chemical trade, procurement is primarily bifurcated into its crystalline free base (CAS 94-15-5) and its hydrochloride salt derivative (CAS 553-63-9). Modern analytical laboratories demand high-crystallinity powders with unambiguous thermodynamic stability profiles, driving manufacturers to abandon crude batch precipitates in favor of controlled solvent crystallization.
The global fine chemical marketplace has transitioned from legacy transactional buying to high-scrutiny vendor qualification frameworks. In analytical chemistry, biochemistry laboratories, and fine organic synthesis programs across North America, the European Union, and the Asia-Pacific region, procurement specialists are actively screening out unverified brokerage intermediaries in search of direct synthesis manufacturers.
The primary driver behind this structural shift is the imperative for verifiable batch-to-batch consistency. A minor 0.5% fluctuation in reactive byproducts—such as unreacted 4-aminobenzoyl chloride or 3-diethylamino-2,2-dimethylpropanol precursors—can compromise complex downstream derivatization yields, leading enterprise buyers to mandate complete impurity profiling before purchase order issuance.
In accordance with global regulatory shifts—including European REACH frameworks, US TSCA guidelines, and regional hazardous material classification systems—suppliers of CAS 94-15-5 must demonstrate authentic regulatory authority and technical competence. Legitimate procurement channels require non-negotiable delivery of 16-section Safety Data Sheets (GHS Rev. 9), detailed Certificates of Analysis (COA), and documented synthetic route clearances.
Hebei Miaoou Technology Co., Ltd. operates under strict quality management systems (ISO 9001:2015), guaranteeing that every batch released for export is fully accounted for with valid spectroscopic and chromatographic verification, eliminating the regulatory compliance hazards typically associated with informal supply pipelines.
Exhaustive physicochemical constants, chromatographic resolution targets, and release criteria implemented across our state-of-the-art analytical testing suite.
| Analytical Parameter | Technical Specification (Free Base) | Technical Specification (HCl Salt) | Standard Test Methodology |
|---|---|---|---|
| CAS Registry Number | 94-15-5 | 553-63-9 | CAS Verification Standard |
| IUPAC Name | (3-diethylamino-2,2-dimethylpropyl) 4-aminobenzoate | (3-diethylamino-2,2-dimethylpropyl) 4-aminobenzoate hydrochloride | IUPAC Gold Book Standard |
| Physical State & Appearance | Off-white to Pale Yellow Viscous Liquid / Low-Melting Solid | White to Off-White Microcrystalline Powder | Visual Inspection (USP <630>) |
| Assay Purity (HPLC) | ≥98.5% (Area Normalization) | ≥99.0% - 99.8% (UV Peak Area) | RP-HPLC (C18 Column, Gradient MeCN/H2O) |
| Melting Point Range | 53.0°C – 56.0°C | 201.0°C – 203.5°C (Decomposition) | Capillary Melting Method (USP <741>) |
| Identification (Identity) | Matches Standard Spectrum (1H-NMR / FT-IR) | Matches Standard Spectrum (1H-NMR / FT-IR / MS) | Bruker 400 MHz 1H-NMR & LC-MS |
| Loss on Drying (LOD) | ≤1.0% | ≤0.5% | Thermogravimetric Analysis / 105°C Drying |
| Heavy Metals Residue | ≤10 ppm | ≤5 ppm | Inductively Coupled Plasma (ICP-MS) |
| Residual Solvents | Meets USP <467> Class 2/3 limits (DCM <600ppm, EtOH <5000ppm) | Meets USP <467> Class 2/3 limits | Headspace Gas Chromatography (HS-GC-FID) |
Analytical reverse-phase HPLC verification utilizing high-efficiency octadecylsilane columns ensures complete peak separation from synthetic precursor fragments and degradation products, preventing co-elution errors.
Spectroscopic fingerprinting verifies proton resonance peaks characteristic of the neopentyl-like quaternary carbon center [-C(CH3)2-] and the symmetric aromatic ring protons with zero extraneous baseline signals.
Electrospray ionization (ESI-MS) definitively tracks the protonated molecular ion peak [M+H]+ at m/z 279.4, establishing total stoichiometric validation against standard chemical library databases.
Automated coulometric Karl Fischer titration precisely determines residual moisture below 0.3% w/w, guaranteeing product powder flowability and anti-caking shelf life under long-term vacuum-sealed storage.
Addressing the core vulnerabilities in international chemical acquisition: Price unpredictability, batch contamination, freight disruption, and regulatory friction.
By engaging Hebei Miaoou Technology Co., Ltd. directly, enterprise buyers bypass multi-tier chemical brokerage markups. Direct reactor synthesis and in-house preparative purification dramatically lower procurement expenditure while securing volume stability for multi-kilogram to metric-ton recurring contracts.
Our reaction vessels operate under strict GMP-aligned cleanroom segregation protocols. Dedicated stainless steel and glass-lined reactors prevent carryover contamination between amino acid coupling reactions, active pharmaceutical intermediates, and specialized ester synthesis suites.
Chemical intermediates containing tertiary amine functional groups and ester linkages are vulnerable to moisture-driven hydrolytic cleavage. We pack under high-purity dry nitrogen into heavy-gauge aluminium foil pouches, enclosed inside tamper-evident HDPE containers or sealed steel drums.
Operating dedicated export hubs in Shijiazhuang, Hong Kong, and bonded warehouse networks, our logistics infrastructure handles documentation, export declarations, and end-to-end tracked courier or air cargo transit across Europe, the Americas, and Southeast Asia.
A transparent, auditable 5-stage synthesis and analytical quality pipeline ensuring reproducible molecular integrity across every manufacturing cycle.
High-purity 4-nitrobenzoyl chloride or 4-aminobenzoic acid and 3-diethylamino-2,2-dimethylpropanol undergo gas chromatographic and Karl Fischer titration checks before introduction into reactors.
Coupling reaction is carried out under inert nitrogen atmosphere in anhydrous solvent matrices with precise temperature modulation to suppress unwanted elimination or transesterification side-routes.
For nitro-ester synthetic pathways, high-pressure catalytic transfer hydrogenation over Pd/C facilitates quantitative nitro reduction to the primary amine without cleaving the labile ester linkage.
Controlled acidification using anhydrous hydrogen chloride gas in isopropyl alcohol yields the high-melting crystalline hydrochloride salt, followed by multi-stage recrystallization for impurity purging.
The purified crystalline material is dried in rotary vacuum cone dryers to remove solvent traces below ICH guidelines, followed by comprehensive HPLC, MS, and 1H-NMR documentation before release.
Providing enterprise clients across 60+ countries with complete legal clarity, verifiable batch certifications, and seamless B2B customs clearance protocols.
Every commercial order is accompanied by an authenticated Certificate of Analysis (COA) explicitly displaying raw spectral data, HPLC chromatograms with peak area integration tables, and accurate structural formulas. SDS documentation is continually updated in alignment with European Chemicals Agency (ECHA) updates and GHS Revision 9 standards.
Our dedicated customs documentation team executes standard CIF, CIP, DDP, and FOB agreements according to Incoterms 2020. Special tariff classification codes (HS Code 292249) are properly declared with dual-use validation papers to eliminate customs port impoundment risks and bureaucratic delays.
Clients are assigned dedicated technical sales managers fluent in chemical synthesis and analytical chemistry. Technical inquiries—such as formulation compatibility questions, solubility queries, or bulk repackaging specifications—receive direct, expert-level feedback within 24 business hours.
Anticipating next-generation production benchmarks through automated microchannel synthesis and eco-conscious atom-economy engineering.
Transitioning from traditional stirred batch tanks to automated tubular microreactors enables ultra-precise residence time control and optimal exothermic heat dissipation during acid chloride addition, boosting overall chemical conversion efficiency above 96% while slashing thermal decomposition risks.
By phasing out conventional hazardous halogenated solvents like dichloromethane in favor of renewable 2-methyltetrahydrofuran (2-MeTHF) and cyclopentyl methyl ether (CPME), we reduce environmental toxicity and VOC footprints while improving closed-loop solvent reclamation to over 92% across production cycles.
Integration of real-time Process Analytical Technology (PAT) incorporating in-line Fourier Transform Infrared (FTIR) spectroscopy and high-speed HPLC sampling algorithms enables instantaneous detection of trace impurities, providing automated corrective feedback to maintain uncompromising synthesis quality.
Authoritative technical, analytical, and operational answers addressing the mission-critical inquiries of laboratory buyers and supply chain managers.
CAS 94-15-5 denotes the free base form of (3-diethylamino-2,2-dimethylpropyl) 4-aminobenzoate, characterized as a low-melting crystalline solid or viscous oily liquid with limited aqueous solubility and strong lipophilicity. In contrast, CAS 553-63-9 represents the hydrochloride salt (Dimethocaine HCl), a highly stable, non-hygroscopic white microcrystalline powder featuring high water solubility and a distinct melting decomposition range of 201°C–203.5°C. For analytical calibration standards and aqueous bio-assay modeling, the hydrochloride salt is typically preferred due to its superior stability and ease of volumetric handling.
Every batch lot synthesized at our facility is subjected to rigorous high-resolution RP-HPLC coupled with photodiode array (PDA) detection and electrospray ionization mass spectrometry (LC-MS). We quantify known precursor traces—including unreacted 4-aminobenzoic acid (PABA), 4-nitrobenzoic acid derivatives, and diethylamino-dimethylpropanol—against validated calibration curves, ensuring no single unknown impurity exceeds 0.1% area normalization, with total assay purity consistently reaching or exceeding 99.0%.
To maintain structural stability and inhibit hydrolytic cleavage of the ester bond, CAS 94-15-5 and its corresponding salt should be stored in hermetically sealed, light-resistant containers purged with high-purity inert nitrogen gas. Storage conditions should be maintained at 2°C to 8°C in a desiccated environment protected from moisture and strong actinic light. Under these validated storage parameters, re-testing intervals can be extended to 24 months with zero detectable chemical degradation.
Commercial shipments from Hebei Miaoou Technology Co., Ltd. are accompanied by a comprehensive documentation packet designed to satisfy international customs and carrier compliance. This includes: (1) Lot-specific Certificate of Analysis (COA) with raw HPLC/MS spectral scans, (2) 16-section Safety Data Sheet (SDS/MSDS) compliant with GHS Rev. 9, (3) Formal Commercial Invoice and Packing List specifying exact HS classification codes, (4) Non-Hazardous / Controlled Substance Status Declarations where applicable, and (5) Certificate of Origin (COO).
Yes. We accommodate diverse client requirements ranging from research-grade pre-aliquoted 1g, 5g, and 10g laboratory vials up to bulk industrial 1kg vacuum aluminium pouches and 25kg UN-rated fiber drums. Batch labeling can be customized to incorporate client catalog numbers, lot designations, internal QR codes, and barcoding for automated warehouse integration.
For stocked batch quantities up to 50 kg, dispatch occurs within 24 to 48 hours following proforma invoice settlement and export documentation approval. For scaled custom synthesis campaigns exceeding 100 kg to metric-ton lots, lead times range between 2 to 4 weeks, with periodic in-process progress updates and HPLC check-in data delivered directly to the purchasing entity.
Explore our extended research catalog: Batch-verified purity, competitive bulk pricing, and rapid delivery backed by ISO-accredited production facilities.
